Fourth Military Medical University, Xijing Hospital of Digestive Diseases, State Key Laboratory of Cancer Biology, Xi'an, Shaanxi Province, China.
Expert Opin Investig Drugs. 2011 May;20(5):637-44. doi: 10.1517/13543784.2011.571203. Epub 2011 Mar 28.
Angiogenesis has become an appealing target in cancer therapy due to its fundamental role in cancer growth and metastasis. A number of angiogenesis-related molecules are under investigation, with some already in clinical practice with various results. The effort to present and discuss the current status of the research on the angiogenesis-related molecular targets will lead to improved clinical strategies and outcomes for patients with esophageal cancer (EC).
This review summarizes the recent advances in angiogenesis-related targets in EC, and also analyzes the clinical and therapeutic applications they provide. We envisage future developments towards the anti-angiogenic strategy of molecular targets and their potential applications to cancer treatment.
Angiogenesis-related targets can be used as a useful therapeutic tool for EC. More investigations should be performed to promote the success of anti-angiogenic therapy in clinical trials.
由于血管生成在癌症生长和转移中起着基本作用，因此它已成为癌症治疗中一个有吸引力的靶点。目前正在研究许多与血管生成相关的分子，其中一些已经在临床实践中应用，结果各不相同。努力展示和讨论与血管生成相关的分子靶点的研究现状，将为食管癌（EC）患者带来改善的临床策略和结果。
本综述总结了 EC 中与血管生成相关的靶点的最新进展，并分析了它们提供的临床和治疗应用。我们设想未来朝着抗血管生成的分子靶点策略以及它们在癌症治疗中的潜在应用方向发展。
与血管生成相关的靶点可作为 EC 的有用治疗工具。应该进行更多的研究以促进抗血管生成疗法在临床试验中的成功。
