家族性双相情感障碍 I 型患者及其未受影响亲属的执行功能。
Executive functioning in familial bipolar I disorder patients and their unaffected relatives.
机构信息
King's Health Partners, Institute of Psychiatry, Department of Psychosis Studies and Department of Psychology, King's College London, NIHR Biomedical Research Centre, London, UK.
出版信息
Bipolar Disord. 2011 Mar;13(2):208-16. doi: 10.1111/j.1399-5618.2011.00901.x.
OBJECTIVE
To compare the executive function of patients with familial bipolar I disorder (BP-I) with a history of psychotic symptoms to their first-degree relatives and normal controls.
METHODS
Three domains of executive function: response inhibition, working memory, and cognitive set shifting were assessed in 44 familial patients with a lifetime diagnosis of BP-I who had experienced psychotic symptoms, 42 of their unaffected first-degree relatives, and 47 controls.
RESULTS
Bipolar disorder patients and their unaffected relatives had significantly worse scores for response inhibition compared to healthy controls. The groups did not differ in working memory or cognitive set shifting.
CONCLUSIONS
Impairments in response inhibition are associated with both psychotic bipolar disorder and genetic liability for this illness. Our results indicate that deficits in this specific domain of executive functioning are a promising candidate endophenotype for psychotic bipolar disorder.
目的
比较有精神病性症状家族性双相 I 障碍（BP-I）病史患者的执行功能与其一级亲属和正常对照。
方法
对 44 例有终生 BP-I 诊断且有精神病性症状的家族性患者、42 例未受影响的一级亲属和 47 例对照进行了 3 个执行功能领域的评估：反应抑制、工作记忆和认知转换。
结果
与健康对照组相比，双相障碍患者及其未受影响的亲属在反应抑制方面的评分明显较差。三组在工作记忆或认知转换方面没有差异。
结论
反应抑制受损与精神病性双相障碍和该病的遗传易感性有关。我们的结果表明，在执行功能的这一特定领域存在缺陷是精神病性双相障碍的一个很有前途的候选内表型。
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