Division of Gastroenterology, Department of Medicine, Faculty of Medicine, University of Malaya, Malaysia.
J Gastroenterol Hepatol. 2011 Apr;26 Suppl 3:49-52. doi: 10.1111/j.1440-1746.2011.06656.x.
The role of psychological disturbance in the pathogenesis of functional dyspepsia is uncertain. We aimed to examine for differences in anxiety, depression and health-related quality of life (HRQOL) between adults with organic (OD) and functional dyspepsia (FD).
A prospective, cross-sectional study of Malaysian adults undergoing oesophago-gastro-duodenoscopy (OGDS) for the primary indication of dyspepsia was conducted. Prior to OGDS, locally translated and validated versions of the Hospital Anxiety and Depression Scale (HADS), Nepean Dyspepsia Index (NDI) and Leeds Dyspepsia Questionnaire (LDQ) were administered.
839 patients (mean age 49.6 ± 15.8 years, 55.7% female, ethnic division: Malays 30.5% , Chinese 38.4%, Indians 29.4%) were studied between June 2008 and March 2009. 472 (56.3%) and 367 (43.7%) patients had FD and OD respectively. There was no difference in the mean LDQ score between FD and OD patients (18.6 vs 18.1, P = 0.4). Moderate/severe anxiety was more prevalent in FD compared to OD patients (28.5% vs 23.1%, P = 0.05) but there was no significant difference in depression. Summary scores for the NDI revealed a lower mean value in FD patients compared to OD patients (68.6 ± 19.5 vs 71.4 ± 19.6, P = 0.04).
Patients with FD have a lower HRQOL compared to those with OD, but this could not be attributed to differences in anxiety nor depression between both groups.
心理障碍在功能性消化不良发病机制中的作用尚不确定。我们旨在研究器质性消化不良（OD）和功能性消化不良（FD）患者之间在焦虑、抑郁和健康相关生活质量（HRQOL）方面的差异。
对因消化不良行食管胃十二指肠镜检查（OGDS）的马来西亚成年人进行前瞻性、横断面研究。在 OGDS 之前，使用经过本地化翻译和验证的医院焦虑抑郁量表（HADS）、Nepean 消化不良指数（NDI）和 Leeds 消化不良问卷（LDQ）对患者进行评估。
2008 年 6 月至 2009 年 3 月期间，共研究了 839 名患者（平均年龄 49.6±15.8 岁，55.7%为女性，种族分布：马来人 30.5%，华人 38.4%，印度人 29.4%）。472 名（56.3%）和 367 名（43.7%）患者分别患有 FD 和 OD。FD 和 OD 患者的 LDQ 评分无差异（18.6 对 18.1，P=0.4）。FD 患者中度/重度焦虑的发生率高于 OD 患者（28.5%对 23.1%，P=0.05），但抑郁发生率无显著差异。NDI 综合评分显示 FD 患者的平均值低于 OD 患者（68.6±19.5 对 71.4±19.6，P=0.04）。
与 OD 患者相比，FD 患者的 HRQOL 较低，但这不能归因于两组患者之间的焦虑或抑郁差异。
