农村亚洲人群中与消化不良相关的风险因素及其对生活质量的影响。

Risk factors associated with dyspepsia in a rural Asian population and its impact on quality of life.

机构信息

Division of Gastroenterology, Department of Medicine, Faculty of Medicine, University of Malaya, Kuala Lumpur, Malaysia.

出版信息

Am J Gastroenterol. 2010 Apr;105(4):904-12. doi: 10.1038/ajg.2010.26. Epub 2010 Feb 23.

DOI:10.1038/ajg.2010.26

PMID:20179699

Abstract

OBJECTIVES

The epidemiology and impact of dyspepsia in rural Asia remains uncertain. We aimed to determine the prevalence epidemiology and impact of dyspepsia in a rural Malaysian community.

METHODS

A door-to-door survey was conducted in a representative rural population in Malaysia. Dyspepsia was defined according to the Rome II criteria, and health-related quality of life (HRQOL) was assessed using the Euroqol (EQ-5D) instrument.

RESULTS

Of 2,260 adults, 2,000 (88.5%) completed the survey. The mean age of respondents was 40.4+/-15.3 years, 62.7% were women, 79.0% were ethnic Malays, 8.4% had been educated up to the tertiary level, 49.7% were unemployed, and 63.4% resided in village-type housing with 49.1% having >8 residents per household. Dyspepsia was prevalent in 292 (14.6%) adults, and they had lower mean EQ-5D utility scores compared with healthy controls (0.91+/-0.17 vs. 0.97+/-0.08, P<0.0001). Dyspepsia was found to be associated with female gender (15.8 vs. 12.7% males, P=0.058), Chinese ethnicity (19.7 vs. 14.2% non-Chinese), higher education levels, medium-range incomes (19.1% medium range vs. 13.3% low range), non-village-type housing (16.3 vs. 13.5% village-type house, P=0.08), nonsmokers (18.7 vs. 13.7%, P=0.015), non-tea drinkers (19.5 vs. 12.3%, P<0.0001), regular analgesia intake (27 vs. 12.7%, P<0.0001), and adults with chronic illness (26.6 vs. 11.1%, P<0.0001). Logistic regression analysis showed that higher levels of education, i.e., secondary (odds ratio (OR) 2.13, 95% confidence interval (CI)=1.15-3.93) and tertiary (2.70, 95% CI=1.30-5.62) education, non-village housing (OR 1.36, 95% CI=1.02-1.80), regular analgesia (OR 2.22, 95% CI=1.60-3.09), and chronic illness (OR 2.83, 95% CI=2.12-3.77) were independent risk factors for dyspepsia. Conversely, regular tea drinking (OR 0.59) seemed to have an inverse relationship.

CONCLUSIONS

Dyspepsia in rural Malaysians is associated with a lower HRQOL. Epidemiological risk factors include a higher socioeconomic status, regular analgesic consumption, and chronic illness.

摘要

目的

亚洲农村地区消化不良的流行病学和影响仍不确定。我们旨在确定马来西亚农村社区消化不良的流行情况和影响。

方法

在马来西亚的一个代表性农村地区进行了逐户调查。消化不良根据罗马 II 标准定义，使用 Euroqol（EQ-5D）工具评估健康相关生活质量（HRQOL）。

结果

在 2260 名成年人中，有 2000 人（88.5%）完成了调查。受访者的平均年龄为 40.4±15.3 岁，62.7%为女性，79.0%为马来族，8.4%受过高等教育，49.7%失业，63.4%居住在村类型住房，49.1%每户有>8 名居民。消化不良在 292 名（14.6%）成年人中很常见，与健康对照组相比，他们的平均 EQ-5D 效用评分较低（0.91±0.17 与 0.97±0.08，P<0.0001）。发现消化不良与女性性别（15.8%与 12.7%男性，P=0.058）、华族种族（19.7%与 14.2%非华族）、较高的教育水平、中等收入范围（19.1%中等范围与 13.3%低范围）、非村类型住房（16.3%与 13.5%村类型房屋，P=0.08）、不吸烟者（18.7%与 13.7%，P=0.015）、不饮茶者（19.5%与 12.3%，P<0.0001）、经常服用镇痛药（27%与 12.7%，P<0.0001）和患有慢性疾病的成年人（26.6%与 11.1%，P<0.0001）相关。逻辑回归分析表明，较高的教育水平，即中等教育（优势比（OR）2.13，95%置信区间（CI）=1.15-3.93）和高等教育（OR 2.70，95%CI=1.30-5.62），非村住房（OR 1.36，95%CI=1.02-1.80），定期服用镇痛药（OR 2.22，95%CI=1.60-3.09）和慢性疾病（OR 2.83，95%CI=2.12-3.77）是消化不良的独立危险因素。相反，经常喝茶（OR 0.59）似乎呈负相关关系。