Department of Medicine, School of Medical Sciences, Universiti Sains Malaysia, Kubang Kerian, Kelantan, Malaysia.
BMC Gastroenterol. 2013 May 14;13:84. doi: 10.1186/1471-230X-13-84.
The study aimed to survey for FD in a primary care setting in a population known to have an extremely low prevalence of Helicobacter pylori (H. pylori) infection, with the hypothesis that in such a population, dyspepsia should have been relatively less common.
The Rome III FD Diagnostic Questionnaire was translated into the Malay language and later tested for reliability. A prospective cross-sectional survey was then performed involving 160 Malay patients attending primary care clinic after informed consent. Patients positive for symptoms of FD were subjected to upper endoscopy and exclusion of H. pylori infection. Univariable and multivariable analyses were used to test for associated risk factors.
The back-translated questionnaire was similar to the original English version and was reliable (Cronbach Alpha-coefficient 0.85). Of the 160 surveyed subjects, 19 of them (11.9%) had symptoms of FD. With exclusion of erosive diseases (3/160 or 1.9%) from endoscopy, 16 subjects or 10% had FD. None of the 19 subjects were positive for H. pylori infection. Epigastric pain syndrome was present in 11/16 (68.8%) and the rest, overlap with postprandial distress syndrome. With multivariable analysis, a married status (OR = 8.1; 95% CI 1.0-36.5) and positive psychosocial alarm symptoms (OR = 3.8; 95% CI 1.0-14.0) were associated with FD. Of those married subjects, females were more likely to have FD and psychosocial symptoms than men (6.3% vs. 1.9%), P = 0.04.
FD was more common than one had expected among Malays attending primary care clinic in an area with low prevalence of H. pylori.
本研究旨在对一个已知幽门螺杆菌（H. pylori）感染率极低的初级保健环境中的功能性消化不良（FD）进行调查，假设在这样的人群中，消化不良的发病率应该相对较低。
将 Rome III FD 诊断问卷翻译成马来语，随后进行可靠性测试。随后，对 160 名马来患者进行了前瞻性横断面调查，这些患者在知情同意后在初级保健诊所就诊。对 FD 症状阳性的患者进行上消化道内镜检查并排除 H. pylori 感染。采用单变量和多变量分析来检测相关的危险因素。
反向翻译的问卷与原始英文版本相似，具有可靠性（Cronbach Alpha 系数 0.85）。在接受调查的 160 名患者中，有 19 名（11.9%）有 FD 症状。排除内镜下发现的糜烂性疾病（160 例中的 3 例，1.9%）后，有 16 例（10%）患有 FD。19 例患者均未检出 H. pylori 感染。上腹痛综合征 11 例（68.8%），其余患者为餐后不适综合征重叠。多变量分析显示，已婚状态（OR=8.1；95%CI 1.0-36.5）和阳性心理社会报警症状（OR=3.8；95%CI 1.0-14.0）与 FD 相关。在已婚患者中，女性患 FD 和心理社会症状的可能性高于男性（6.3%对 1.9%），P=0.04。
在幽门螺杆菌感染率较低的地区，马来人在初级保健诊所就诊时，FD 的发病率高于预期。
