副肿瘤性肌肉疾病。

Paraneoplastic muscle disease.

机构信息

Division of Rheumatology, Johns Hopkins University School of Medicine, Good Samaritan Hospital, 5200 Eastern Avenue, Mason F. Lord Building Center Tower, Suite 4100, Room 413, Baltimore MD 21224, USA.

出版信息

Rheum Dis Clin North Am. 2011 May;37(2):185-200, v-vi. doi: 10.1016/j.rdc.2011.01.011.

DOI:10.1016/j.rdc.2011.01.011

PMID:21444019

Abstract

In paraneoplastic muscle disease, the malignancy may remotely affect neuromuscular transmission or incite muscle inflammation or necrosis. In several of these diseases, an autoimmune basis for the muscle disease has been established and has become a defining feature. These paraneoplastic muscle diseases may be the first manifestation of a malignancy, and their diagnosis thus demands a vigilant search for an underlying tumor. This article is focused on inflammatory and necrotizing myopathies and disorders of neuromuscular transmission that may arise in the setting of malignancy and are considered paraneoplastic phenomena.

摘要

在副肿瘤性肌肉疾病中，恶性肿瘤可能会对神经肌肉传递产生远程影响，或者引发肌肉炎症或坏死。在这些疾病中的几种中，肌肉疾病的自身免疫基础已经确立，并成为一个明确的特征。这些副肿瘤性肌肉疾病可能是恶性肿瘤的首发表现，因此其诊断需要警惕寻找潜在的肿瘤。本文重点介绍可能在恶性肿瘤背景下发生的炎症性和坏死性肌病以及神经肌肉传递障碍，这些被认为是副肿瘤现象。