Department of Obstetrics and Gynecology, Peking Union Medical College Hospital, Peking Union Medical College, Chinese Academy of Medical Sciences, Beijing, PR, China.
J Gynecol Oncol. 2019 Nov;30(6):e99. doi: 10.3802/jgo.2019.30.e99.
To analyze the clinical characteristics, prognosis and parallel clinical course of ovarian cancer (OC) and dermatomyositis (DM).
The medical records of 23 consecutive patients who were diagnosed with OC and DM and were treated at Peking Union Medical College Hospital (PUMCH) between 2002 and 2017 were reviewed. Propensity score matching method was used to match control group (OC patients without DM) at a ratio of 1:5. The correlation between OC and DM was measured using the Pearson correlation scatter plot and Pearson's r. Kaplan-Meier survival analysis and Cox proportional hazard regression analysis were performed to evaluate the prognostic factors.
After matching, 23 patients who have the concurrence of OC and DM (DM group) and 115 patients diagnosed with OC alone (No DM group) were included. The 5-year overall survival rates (71.6% vs. 51.8%, p=0.020) and 5-year progression-free survival (30.5% vs. 0%, p=0.018) were poorer in DM group. Correlation between serum cancer antigen 125 (CA 125) and creatine kinase (CK) level was observed in 12 patients. The time between OC and DM diagnosis is significant through univariable analysis (p=0.021) but not in multivariable analysis in patients who have the concurrence of OC and DM.
The concurrence of OC and DM as a paraneoplastic syndrome is rare and has a poor prognosis. The risk for patients diagnosed with DM is highest within 3 years before or after OC diagnosis. A correlation and a parallel clinical course exist between these 2 diseases.
分析卵巢癌（OC）和皮肌炎（DM）的临床特征、预后和并行临床过程。
回顾性分析 2002 年至 2017 年期间在北京协和医院诊断为 OC 合并 DM 的 23 例患者的临床资料。采用倾向性评分匹配方法，以 1：5 的比例匹配 OC 无 DM 对照组。采用 Pearson 相关散点图和 Pearson r 评估 OC 和 DM 之间的相关性。采用 Kaplan-Meier 生存分析和 Cox 比例风险回归分析评估预后因素。
匹配后，共纳入 23 例 OC 合并 DM 患者（DM 组）和 115 例 OC 患者（No DM 组）。DM 组的 5 年总生存率（71.6%比 51.8%，p=0.020）和 5 年无进展生存率（30.5%比 0%，p=0.018）均较差。12 例患者观察到血清癌抗原 125（CA 125）和肌酸激酶（CK）水平之间存在相关性。在 OC 和 DM 并存的患者中，单变量分析显示 OC 和 DM 诊断之间的时间有显著差异（p=0.021），但多变量分析中无差异。
OC 和 DM 作为副肿瘤综合征并存罕见，预后较差。DM 患者在 OC 诊断前 3 年或诊断后 3 年风险最高。这两种疾病之间存在相关性和并行临床过程。
