妊娠期血栓形成倾向。

Thrombophilias in pregnancy.

机构信息

Division of Hematology, Brigham and Women's Hospital, Harvard Medical School, Boston, MA 02115, USA.

出版信息

Hematol Oncol Clin North Am. 2011 Apr;25(2):323-33, viii. doi: 10.1016/j.hoc.2011.02.003.

DOI:10.1016/j.hoc.2011.02.003

Abstract

Thrombophilic conditions are associated with an increased risk of venous thromboembolic events (VTE) during pregnancy. Thrombophilic disorders are either acquired, as in antiphospholipid syndrome, or inherited, as in factor V Leiden. Both are associated with VTE but acquired disorders can also increase the risk of arterial events. However, there is controversy as to whether they may adversely affect other pregnancy outcomes including pregnancy loss, placental abruption, severe preeclampsia, and stillbirth. This article discusses the effect of thrombophilias on pregnancy.

摘要

血栓形成倾向与妊娠期间静脉血栓栓塞事件 (VTE) 的风险增加有关。血栓形成倾向可以是获得性的，如抗磷脂综合征，也可以是遗传性的，如因子 V Leiden 突变。两者都与 VTE 相关，但获得性疾病也会增加动脉事件的风险。然而，关于它们是否会对其他妊娠结局（包括流产、胎盘早剥、重度子痫前期和死产）产生不利影响，仍存在争议。本文讨论了血栓形成倾向对妊娠的影响。