暂时性骨髓增殖性疾病中的21三体综合征。

Trisomy 21 in transient myeloproliferative disorder.

作者信息

Faed M J, Robertson J, Todd A S, Sivakumaran M, Tarnow-Mordi W O

机构信息

Department of Pathology, University of Dundee, Scotland.

出版信息

Cancer Genet Cytogenet. 1990 Sep;48(2):259-64. doi: 10.1016/0165-4608(90)90129-x.

DOI:10.1016/0165-4608(90)90129-x

PMID:2144465

Abstract

Transient leukemia in phenotypically normal children is rare. A newborn child in whom fever and tachypnea developed at age 2 days had a white blood cell count of 20.1 x 10(9)/L and many abnormal blast cells. Chromosome analysis of spontaneously dividing cells from the blood showed these to have trisomy 21, and 80% of cells in the marrow were also trisomic. No trisomic cells were present in skin fibroblast cultures. At age 6 months, at which time the blood film appeared normal, trisomic cells were no longer present.

摘要

表型正常儿童的短暂性白血病很罕见。一名2日龄出现发热和呼吸急促的新生儿白细胞计数为20.1×10⁹/L，并有许多异常原始细胞。对血液中自发分裂细胞的染色体分析显示这些细胞存在21三体，骨髓中80%的细胞也为三体。皮肤成纤维细胞培养物中不存在三体细胞。6个月大时，此时血涂片看起来正常，三体细胞不再存在。