Limper M, Eeftinck Schattenkerk D, de Kruif M D, van Wissen M, Brandjes D P M, Duits A J, van Gorp E C M
Department of Internal Medicine, Slotervaart Hospital, The Netherlands.
Neth J Med. 2011 Mar;69(3):124-8.
Although fever is recognised as a major presentation symptom at Emergency Departments (EDs) and is often used as a rationale for the institution of antibiotics, few studies describing patients with fever as the sole inclusion criterion at the ED of a general hospital have been performed. The objective of this study is to describe epidemiology of non-surgical febrile patients at the ED and to identify risk factors for adverse outcome.
Blood, sputum, urine and faeces cultures, urine sediments and throat swaps for viral diagnostics were obtained from febrile ED patients. Outcome parameters were bacterial/viral infection, non-bacterial/non-viral infection, non-infectious febrile disease; mortality, hospital admission, admission to the intensive care unit (ICU) and length of hospital stay.
213 Patients were included (87.8% were hospitalised, 8.5% were admitted to ICU, 4.2% died). In 75 patients (35.2%), bacterial infection was confirmed; in 78 patients (36.6%) bacterial infection was suspected. In nine patients (4.2%), viral diagnosis was confirmed; in six patients (2.8%), a viral condition was suspected. The most frequently encountered infection was bacterial pneumonia (58 patients, 27.2%). Only older age was correlated with mortality (ρ=0.176, p=0.01).
A majority of the febrile patients were admitted to the hospital, mostly for bacterial infection. An overall mortality rate of 4.2% was registered. Only a few risk factors for adverse outcome could be identified in this cohort. Overall, the outcome of patients presenting with fever at the ED is rather benign.
尽管发热被认为是急诊科的主要症状表现,且常被用作使用抗生素的理由,但很少有研究以发热作为综合医院急诊科唯一纳入标准来描述患者情况。本研究的目的是描述急诊科非手术发热患者的流行病学特征,并确定不良结局的危险因素。
从急诊科发热患者处获取血液、痰液、尿液和粪便培养物、尿沉渣以及用于病毒诊断的咽拭子。结局参数包括细菌/病毒感染、非细菌/非病毒感染、非感染性发热疾病;死亡率、住院情况、入住重症监护病房(ICU)情况以及住院时间。
纳入213例患者(87.8%住院,8.5%入住ICU,4.2%死亡)。75例患者(35.2%)确诊为细菌感染;78例患者(36.6%)疑似细菌感染。9例患者(4.2%)确诊病毒感染;6例患者(2.8%)疑似病毒感染。最常见的感染是细菌性肺炎(58例,27.2%)。仅年龄较大与死亡率相关(ρ=0.176,p=0.01)。
大多数发热患者住院,主要是因为细菌感染。总体死亡率为4.2%。在该队列中仅能确定少数不良结局的危险因素。总体而言,急诊科发热患者的结局较为良好。