Carrion Ricardo, Patterson Jean L
Department of Virology and Immunology, Southwest National Primate Research Center, Southwest Foundation for Biomedical Research, San Antonio, TX, USA.
Hum Vaccin. 2011 Jun;7(6):667-73. doi: 10.4161/hv.7.6.14981. Epub 2011 Jun 1.
Viral hemorrhagic fevers are a group of disease syndromes caused by infection with certain RNA viruses. The disease is marked by a febrile response, malaise, coagulopathy and vascular permeability culminating in death. Case fatality rates can reach 90% depending on the etiologic agent. Currently, there is no approved antiviral treatment. Because of the high case fatality, risk of importation and the potential to use these agents as biological weapons, development of countermeasures to these agents is a high priority. The sporadic nature of disease outbreaks and the ethical issues associated with conducting a human trial for such diseases make human studies impractical; therefore, development of countermeasures must occur in relevant animal models. Non-human primates are superior models to study infectious disease because their immune system is similar to humans and they are good predictors of efficacy in vaccine development and other intervention strategies. This review article summarizes viral hemorrhagic fever non-human primate models.
病毒性出血热是由某些RNA病毒感染引起的一组疾病综合征。该疾病的特征是发热反应、不适、凝血病和血管通透性，最终导致死亡。根据病原体的不同，病死率可达90%。目前，尚无批准的抗病毒治疗方法。由于病死率高、输入风险以及这些病原体有可能被用作生物武器，针对这些病原体的对策开发是当务之急。疾病暴发的散发性以及针对此类疾病进行人体试验所涉及的伦理问题使得人体研究不切实际；因此，必须在相关动物模型中开展对策开发。非人灵长类动物是研究传染病的优质模型，因为它们的免疫系统与人类相似，并且在疫苗开发和其他干预策略中是疗效的良好预测指标。这篇综述文章总结了病毒性出血热非人灵长类动物模型。
