猿猴出血热病毒感染恒河猴作为病毒性出血热模型：临床特征和重症疾病的危险因素。

Simian hemorrhagic fever virus infection of rhesus macaques as a model of viral hemorrhagic fever: clinical characterization and risk factors for severe disease.

机构信息

Emerging Viral Pathogens Section, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892, USA.

出版信息

Virology. 2011 Dec 20;421(2):129-40. doi: 10.1016/j.virol.2011.09.016. Epub 2011 Oct 19.

DOI:10.1016/j.virol.2011.09.016

PMID:22014505

原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC3210905/

Abstract

Simian Hemorrhagic Fever Virus (SHFV) has caused sporadic outbreaks of hemorrhagic fevers in macaques at primate research facilities. SHFV is a BSL-2 pathogen that has not been linked to human disease; as such, investigation of SHFV pathogenesis in non-human primates (NHPs) could serve as a model for hemorrhagic fever viruses such as Ebola, Marburg, and Lassa viruses. Here we describe the pathogenesis of SHFV in rhesus macaques inoculated with doses ranging from 50 PFU to 500,000 PFU. Disease severity was independent of dose with an overall mortality rate of 64% with signs of hemorrhagic fever and multiple organ system involvement. Analyses comparing survivors and non-survivors were performed to identify factors associated with survival revealing differences in the kinetics of viremia, immunosuppression, and regulation of hemostasis. Notable similarities between the pathogenesis of SHFV in NHPs and hemorrhagic fever viruses in humans suggest that SHFV may serve as a suitable model of BSL-4 pathogens.

摘要

猿猴出血热病毒（SHFV）已导致灵长类动物研究设施中猕猴发生散发性出血热。SHFV 是一种 BSL-2 病原体，与人类疾病无关；因此，对非人类灵长类动物（NHP）中 SHFV 发病机制的研究可以作为埃博拉、马尔堡和拉萨病毒等出血热病毒的模型。在这里，我们描述了接种剂量为 50 PFU 至 500,000 PFU 的食蟹猴中 SHFV 的发病机制。疾病的严重程度与剂量无关，总死亡率为 64%，出现出血热和多个器官系统受累的症状。为了确定与存活相关的因素，对幸存者和非幸存者进行了分析，结果表明，病毒血症、免疫抑制和止血调节的动力学存在差异。NHP 中 SHFV 的发病机制与人类出血热病毒之间存在显著相似性，这表明 SHFV 可能是一种合适的 BSL-4 病原体模型。