Advanced Materials Laboratory, Department of Materials Science and Engineering, Tsinghua University, Beijing, 100084, China.
Ann Biomed Eng. 2011 Jul;39(7):1857-71. doi: 10.1007/s10439-011-0300-y. Epub 2011 Mar 29.
In recent years, research on magnesium (Mg) alloys had increased significantly for hard tissue replacement and stent application due to their outstanding advantages. Firstly, Mg alloys have mechanical properties similar to bone which avoid stress shielding. Secondly, they are biocompatible essential to the human metabolism as a factor for many enzymes. In addition, main degradation product Mg is an essential trace element for human enzymes. The most important reason is they are perfectly biodegradable in the body fluid. However, extremely high degradation rate, resulting in too rapid loss of mechanical strength in chloride containing environments limits their applications. Engineered artificial biomaterials with appropriate mechanical properties, surface chemistry, and surface topography are in a great demand. As the interaction between the cells and tissues with biomaterials at the tissue--implant interface is a surface phenomenon; surface properties play a major role in determining both the biological response to implants and the material response to the physiological condition. Therefore, the ability to modify the surface properties while preserve the bulk properties is important, and surface modification to form a hard, biocompatible and corrosion resistant modified layer have always been an interesting topic in biomaterials field. In this article, attempts are made to give an overview of the current research and development status of surface modification technologies of Mg alloys for biomedical materials research. Further, the advantages/disadvantages of the different methods and with regard to the most promising method for Mg alloys are discussed. Finally, the scientific challenges are proposed based on own research and the work of other scientists.
近年来，由于镁 (Mg) 合金具有出色的优势，其在硬组织替代和支架应用方面的研究显著增加。首先，镁合金具有类似于骨骼的机械性能，可以避免应力屏蔽。其次，它们具有生物相容性，是许多酶的人类新陈代谢所必需的因素。此外，主要降解产物 Mg 是人类酶的必需微量元素。最重要的原因是它们在体液中完全可生物降解。然而，在含有氯离子的环境中，极高的降解率会导致机械强度过快丧失，从而限制了其应用。具有适当机械性能、表面化学性质和表面形貌的工程人工生物材料需求量很大。由于细胞与组织在组织-植入物界面处的相互作用是一种表面现象；表面性能在决定植入物的生物反应和材料对生理条件的反应方面起着主要作用。因此，能够在保留本体性能的同时改变表面性能是很重要的，并且形成硬、生物相容和耐腐蚀的改性层的表面改性一直是生物材料领域的一个有趣课题。本文试图概述用于生物医学材料研究的镁合金表面改性技术的当前研究和开发状况。此外，还讨论了不同方法的优缺点，并针对镁合金最有前途的方法进行了讨论。最后，根据自己的研究和其他科学家的工作，提出了科学挑战。
