Department of Anatomy and Structural Biology, University of Otago, Dunedin, New Zealand.
Acta Biomater. 2012 Jan;8(1):20-30. doi: 10.1016/j.actbio.2011.10.016. Epub 2011 Oct 20.
Magnesium has been suggested as a revolutionary biodegradable metal for use as an orthopaedic material. As a biocompatible and degradable metal, it has several advantages over the permanent metallic materials currently in use, including eliminating the effects of stress shielding, improving biocompatibility concerns in vivo and improving degradation properties, removing the requirement of a second surgery for implant removal. The rapid degradation of magnesium, however, is a double-edged sword as it is necessary to control the corrosion rates of the materials to match the rates of bone healing. In response, calcium phosphate coatings have been suggested as a means to control these corrosion rates. The potential calcium phosphate phases and their coating techniques on substrates are numerous and can provide several different properties for different applications. The reactivity and low melting point of magnesium, however, require specific parameters for calcium phosphate coatings to be successful. Within this review, an overview of the different calcium phosphate phases, their properties and their behaviour in vitro and in vivo has been provided, followed by the current coating techniques used for calcium phosphates that may be or may have been adapted for magnesium substrates.
镁被认为是一种革命性的可生物降解金属，可作为骨科材料使用。作为一种生物相容性和可降解的金属，它相对于目前使用的永久性金属材料具有几个优势，包括消除应力屏蔽的影响、提高体内生物相容性问题和改善降解性能，无需进行第二次手术取出植入物。然而，镁的快速降解是一把双刃剑，因为有必要控制材料的腐蚀速率，使其与骨愈合的速率相匹配。为了应对这一问题，已经提出了磷酸钙涂层作为控制这些腐蚀速率的一种手段。具有不同特性的不同应用所需的钙磷相及其在基底上的涂层技术有很多种。然而，镁的反应性和低熔点需要为磷酸钙涂层设定特定的参数才能成功。在这篇综述中，提供了不同钙磷相及其性质的概述，以及它们在体外和体内的行为，然后介绍了目前用于磷酸钙的涂层技术，这些技术可能已经或可能已经适用于镁基底。
