Zorić Lepsa, Colak Emina, Canadanović Vladimir, Kosanović-Jaković Natalija, Kisić Bojana
Klinika za ocne bolesti, Bolnicki centar Kosovska Mitrovica.
Med Pregl. 2010 Jul-Aug;63(7-8):522-6. doi: 10.2298/mpns1008522z.
Age-related cataract not only diminishes human life quality but it also represents a big impact on healthcare budget of almost every country as the population ages globally. Hence, cataract prevention is a big and true challenge, but a very difficult task to be accomplished. Nowadays cataract is more than a routinely recognized and almost always successfully operated ophthalmologic disease. The diagnosis of age-related cataract diagnosis might alert doctors to some systemic disorders on the whole body level. Increasing age is certainly the most essential age-related cataract risk factor. However, it seems that cataract could be a multifactor disease because of its individual, familiar, racial and gender expression differences.
Oxidation stress and its form caused by ultraviolet light- photo-oxidative stress--are considered to be crucial in the etiopathogenesis of cataract. All biomolecules suffer damages during cataract formation. On the other side, the lens possess a range of antioxidant elements and mechanisms of their action, which enable long lasting maintenance of lens transparency and functioning. Although they are primary characteristics of the lens, these antioxidant elements also depend on their systemic availability and consumption. This paper is a short literature review of the relation between oxidation stress and age-related cataract.
随着全球人口老龄化，年龄相关性白内障不仅会降低人类生活质量，还会对几乎每个国家的医疗保健预算产生重大影响。因此，预防白内障是一项重大且切实的挑战，但却是一项极难完成的任务。如今，白内障已不仅仅是一种常规认知且几乎总能成功手术治疗的眼科疾病。年龄相关性白内障的诊断可能会提醒医生注意全身层面的某些系统性疾病。年龄增长无疑是最重要的年龄相关性白内障危险因素。然而，由于白内障在个体、家族、种族和性别表现上存在差异，它似乎可能是一种多因素疾病。
氧化应激及其由紫外线引起的形式——光氧化应激——被认为在白内障的发病机制中起关键作用。在白内障形成过程中，所有生物分子都会受到损伤。另一方面，晶状体拥有一系列抗氧化元素及其作用机制，这些机制能够长期维持晶状体的透明度和功能。尽管这些抗氧化元素是晶状体的主要特征，但它们也依赖于其在全身的可用性和消耗情况。本文是关于氧化应激与年龄相关性白内障之间关系的简短文献综述。
