Zoric L, Miric D, Milenkovic S, Jovanovic P, Trajkovic G
Clinic for Eye Diseases, Faculty of Medicine, University of Pristina, Settlement Kosovska Mitrovica, Serbia and Montenegro.
Eur J Ophthalmol. 2006 Mar-Apr;16(2):268-73. doi: 10.1177/112067210601600212.
Pseudoexfoliation syndrome (PES) seems to be a systemic condition. However, to an ophthalmologist it represents a continual challenge, due to unclear etiology and patho-genesis, and because of a potential for development of an aggressive glaucoma, and cataract surgery complications. According to some findings, PES could be a factor of hastened aging, which means that it could be considered as a secondary aging factor.
Frequencies of secondary aging diseases (non-insulin dependent diabetes mellitus, atherosclerotic myocardiopathy, chronic obstructive lung diseases, arterial hypertension, and PES) were investigated in 162 patients with age-related cataract and 55 age- and sex-matched control subjects, and analyzed by a logistic regression. The authors also determined elements of antioxidative protection in a group of sera from patients with cataract and PES, and compared them to those obtained from patients with cataract without PES (activity of catalase and peroxidase, glutathione, vitamins C and E), and total antioxidative protection (%iMDA). Antioxidant defense of aqueous humors, expressed as a rate of induced malondialdehyde (%iMDA), and total thiol groups in the lens corticonuclear blocks (TSH) were estimated in samples of 17 patients with PES and cataract and 55 patients with cataract only.
Logistic regression showed the highest odds ratio for PES (OR=4.516; p<0.05). Catalytic activity of serum catalase had significantly lower values in patients with PES (p<0.05). Anti oxidative defense of aqueous humor and lens had lower values in patients with PES.
The results indicate that PES might be a significant factor for cataractogenesis. At least a part of pathogenesis alterations in an eye with PES could be the result of higher intensity of oxidative stress.
假性剥脱综合征（PES）似乎是一种全身性疾病。然而，对于眼科医生来说，它仍然是一个持续的挑战，这是由于其病因和发病机制尚不明确，且存在发展为侵袭性青光眼和白内障手术并发症的可能性。根据一些研究结果，PES可能是加速衰老的一个因素，这意味着它可被视为一种继发性衰老因素。
对162例年龄相关性白内障患者和55例年龄及性别匹配的对照受试者的继发性衰老疾病（非胰岛素依赖型糖尿病、动脉粥样硬化性心肌病、慢性阻塞性肺疾病、动脉高血压和PES）发生频率进行调查，并通过逻辑回归分析。作者还测定了白内障合并PES患者血清中的抗氧化保护成分，并将其与无PES的白内障患者的相应成分（过氧化氢酶和过氧化物酶活性、谷胱甘肽、维生素C和E）以及总抗氧化保护（%iMDA）进行比较。在17例PES合并白内障患者和55例单纯白内障患者的样本中，评估了房水的抗氧化防御能力（以诱导丙二醛速率（%iMDA）表示）和晶状体皮质核块中的总巯基（TSH）。
逻辑回归显示PES的优势比最高（OR=4.516；p<0.05）。PES患者血清过氧化氢酶的催化活性显著较低（p<0.05）。PES患者房水和晶状体的抗氧化防御能力较低。
结果表明，PES可能是白内障发生的一个重要因素。PES患者眼中至少部分发病机制改变可能是氧化应激强度较高的结果。
