Oliveira Lucienne C, Azevedo Paula S, Minicucci Marcos E, Rafacho Bruna P M, Duarte Daniella R, Matsubara Luiz S, Matsubara Beatriz B, Paiva Sergio A R, Zornoff Leonardo A M
Department of Internal Medicine, Botucatu Medical School, UNESP-São Paulo State University, Botucatu, Brazil.
Acta Cardiol. 2011 Feb;66(1):3-7. doi: 10.1080/ac.66.1.2064960.
Our objective was to test the hypothesis that retinoic acid supplementation could attenuate ventricular remodelling induced by tobacco smoke exposure in rats.
Wistar rats were allocated into three groups: control (C, n = 8); exposed to tobacco smoke (ETS, n = 9); exposed to tobacco smoke and all-trans-retinoic acid (ETS-RA, n = 9). After two months, cardiac function and geometry were assessed by echocardiography, and geometry changes were confirmed by morphometric analysis. Data are expressed as mean +/- SD or medians (including the lower quartile and upper quartile). ETS showed higher normalized left ventricular diastolic diameters than groups C and ETS-RA (C = 18.4 +/- 3.57 mm/kg, ETS = 23.0 +/- 1.8, ETS-RA = 19.5 +/- 0.99; P <0.05) and systolic diameters (C = 8.25 +/- 2.16 mm/kg, ETS = 11.5 +/- 1.31, ETS-RA = 8.25 +/- 0.71 mm/kg; P < 0.05). ETS showed reduced ejection fraction (C= 91 +/- 2.0, ETS = 87 +/- 3.0, ETS-RA = 92 +/- 3.0; P < 0.05) and fractional shortening (C = 55.8 +/- 4.41%, ETS = 49.7 +/- 4.43%, ETS-RA = 57.6 +/- 5.15 %; P= 0.01) compared to C and ETS-RA. ETS had increased myocyte cross-sectional area (C = 294 +/- 21 mm2, ETS = 352 +/-44, ETS-RA = 310 +/- 35; P < 0.05) compared to C and ETS-RA. Considering all variables, there were no differences between groups C and ETS-RA.
Retinoic acid prevented ventricular remodelling induced by tobacco smoke exposure.
我们的目的是检验以下假设，即补充视黄酸可减轻大鼠因接触烟草烟雾而引起的心室重塑。
将Wistar大鼠分为三组：对照组（C组，n = 8）；接触烟草烟雾组（ETS组，n = 9）；接触烟草烟雾并给予全反式视黄酸组（ETS-RA组，n = 9）。两个月后，通过超声心动图评估心脏功能和几何形态，并通过形态计量分析确认几何形态变化。数据以平均值±标准差或中位数（包括下四分位数和上四分位数）表示。与C组和ETS-RA组相比，ETS组的标准化左心室舒张直径更高（C组=18.4±3.57mm/kg，ETS组=23.0±1.8，ETS-RA组=19.5±0.99；P<0.05），收缩直径也更高（C组=8.25±2.16mm/kg，ETS组=11.5±1.31，ETS-RA组=8.25±0.71mm/kg；P<0.05）。与C组和ETS-RA组相比，ETS组的射血分数降低（C组=91±2.0，ETS组=87±3.0，ETS-RA组=92±3.0；P<0.05），缩短分数也降低（C组=55.8±4.41%，ETS组=49.7±4.43%，ETS-RA组=57.6±5.15%；P = 0.01）。与C组和ETS-RA组相比，ETS组的心肌细胞横截面积增加（C组=294±21mm²，ETS组=352±44，ETS-RA组=310±35；P<0.05）。综合所有变量来看，C组和ETS-RA组之间没有差异。
视黄酸可预防因接触烟草烟雾而引起的心室重塑。
