胃仙-U 对老年痴呆症患者食欲不振的疗效：初步研究。

Effect of Rikkunshi-to on appetite loss found in elderly dementia patients: a preliminary study.

机构信息

Department of Psychiatry, Juntendo Koshigaya Hospital, Juntendo University School of Medicine, Saitama, Japan.

出版信息

Psychogeriatrics. 2011 Mar;11(1):34-9. doi: 10.1111/j.1479-8301.2010.00347.x.

DOI:10.1111/j.1479-8301.2010.00347.x

PMID:21447107

Abstract

BACKGROUND

Functional gastrointestinal symptoms are frequently found in elderly dementia patients. In such a case, we attempt treatment by the administration of antidepressants or second-generation antipsychotics. However, these medications have a risk of side-effects. In the present study, we carried out oral administration of Rikkunshi-to to elderly dementia patients with appetite loss, and examined its effects on food intake.

METHODS

Six elderly dementia patients were recruited from inpatients. They showed appetite loss, but no organic abnormalities of the gastrointestinal organs. These patients were given Rikkunshi-to, at 7.5 g per day, t.i.d. for 4 weeks. We examined the food intake, weight, total protein, albumin and potassium in plasma before administration and for 4 weeks after administration. In statistical analyses, the percentage of food consumed for 4 weeks was analyzed by anova. We also examined the side-effects of Rikkunshi-to.

RESULTS

In patient 3, we stopped investigation after 3 weeks because of the development of cholecystitis. The values of 4 weeks in patient 3 were calculated as the mean values of 4 weeks in the other five patients. anova and Tukey's multiple comparison showed a marginally significant difference in weight between before Rikkunshi-to was given and 4 weeks after. In change of food intake, there were no significant differences between before Rikkunshi-to was given and 1 day after, 1 day and 2 days after, 2 days and 3 days after, 3 days and 1 week after, and 1 week and 2 weeks after; however, there were significant increases in food intake between other times. With regard to the side-effects, mild lower limb oedema appeared in the two patients.

CONCLUSION

In the present study, we showed the effect of Rikkunshi-to in improving appetite loss in elderly dementia patients. The present study suggests that Rikkunshi-to might be useful in improving functional appetite loss in elderly dementia patients, because there are no serious side-effects.

摘要

背景

功能性胃肠道症状在老年痴呆症患者中经常出现。在这种情况下，我们尝试通过给予抗抑郁药或第二代抗精神病药进行治疗。然而，这些药物有副作用的风险。在本研究中，我们对食欲减退的老年痴呆症患者口服给予六君子汤，并检查其对食物摄入的影响。

方法

从住院患者中招募了 6 名老年痴呆症患者。他们表现出食欲减退，但胃肠道器官没有器质性异常。这些患者每天给予 7.5 克六君子汤，分 3 次服用，共 4 周。我们在给药前和给药后 4 周检查食物摄入量、体重、血浆总蛋白、白蛋白和钾。在统计分析中，通过方差分析分析 4 周内消耗的食物百分比。我们还检查了六君子汤的副作用。

结果

在第 3 例患者中，由于胆囊炎的发展，我们在 3 周后停止了调查。第 3 例患者的 4 周值计算为其他 5 例患者的 4 周平均值。方差分析和 Tukey 多重比较显示，给药前和给药后 4 周之间的体重差异具有边缘显著意义。在食物摄入量的变化方面，给药前和给药后 1 天、1 天和 2 天、2 天和 3 天、3 天和 1 周以及 1 周和 2 周之间没有显著差异；然而，在其他时间点，食物摄入量显著增加。关于副作用，两名患者出现轻度下肢水肿。