Neuroscience Institute & Center for Neurocognitive Research, Christian-Doppler-Clinic, Paracelsus Private Medical University, Salzburg, Austria.
Int J Psychophysiol. 2011 Jun;80(3):227-35. doi: 10.1016/j.ijpsycho.2011.03.012. Epub 2011 Apr 5.
In previous studies event-related potentials and oscillations in response to subject's own name have been analyzed extensively on group-level in healthy subjects and in patients with a disorder of consciousness. Subject's own name as a deviant produces a P3. With equiprobable stimuli, non-phase-locked alpha oscillations are smaller in response to subject's own name compared to other names or subject's own name backwards. However, little is known about replicability on a single-subject level. Seventeen healthy subjects were assessed in an own-name paradigm with equiprobable stimuli of subject's own name, another name, and subject's own name backwards. Event-related potentials and non-phase locked oscillations were analyzed with single-subject, non-parametric statistics. No consistent results were found either for ERPs or for the non-phase locked changes of oscillatory activities. Only 4 subjects showed a robust effect as expected, that is, a lower activity in the alpha-beta range to subject's own name compared to other conditions. Four subjects elicited a higher activity for subject's own name. Thus, analyzing the EEG reactivity in the own-name paradigm with equiprobable stimuli on a single-subject level yields a high variance between subjects. In future research, single-subject statistics should be applied for examining the validity of physiologic measurements in other paradigms and for examining the pattern of reactivity in patients.
在先前的研究中，健康受试者和意识障碍患者的群体水平上广泛分析了与自身姓名相关的事件相关电位和振荡。自身姓名作为一种偏差会产生 P3。在等概率刺激的情况下，与其他姓名或自身姓名的反向相比，自身姓名的非锁相α振荡较小。然而，关于个体水平的可重复性知之甚少。17 名健康受试者在自身姓名范式中接受评估，该范式使用等概率的自身姓名、另一个姓名和自身姓名的反向作为刺激。使用单受试者、非参数统计学分析事件相关电位和非锁相振荡。无论是对于 ERPs 还是对于振荡活动的非锁相变化，都没有发现一致的结果。只有 4 名受试者如预期的那样表现出了明显的效果，即与其他条件相比，自身姓名在α-β 范围内的活动较低。4 名受试者对自身姓名的反应更高。因此，在个体水平上用等概率刺激分析自身姓名范式中的 EEG 反应会导致受试者之间的方差很大。在未来的研究中，应将单受试者统计应用于检查其他范式中生理测量的有效性，并检查患者的反应模式。
