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富含绿原酸或 N-甲基吡啶翁的咖啡通过 Nrf2/ARE 通路在体外和体内诱导化学预防相 II 酶。

Coffees rich in chlorogenic acid or N-methylpyridinium induce chemopreventive phase II-enzymes via the Nrf2/ARE pathway in vitro and in vivo.

机构信息

University of Vienna, Department of Food Chemistry and Toxicology, Vienna, Austria.

出版信息

Mol Nutr Food Res. 2011 May;55(5):798-802. doi: 10.1002/mnfr.201100115. Epub 2011 Mar 24.

DOI:10.1002/mnfr.201100115
PMID:21448860
Abstract

Recently, the coffee constituents 5-O-caffeoylquinic acid (CGA) and N-methylpyridinium (NMP) were identified as inducers of the Nrf2/antioxidant-response element (ARE) detoxifying pathway under cell-culture condition. To study the impact of CGA and NMP on the Nrf2-activating properties of a complex coffee beverage, two different model coffees were generated by variation of the roasting conditions: a low-roast coffee rich in CGA and a heavy-roast low in CGA but containing high levels of NMP. Activation of the Nrf2/antioxidant-response element pathway was monitored in vitro and in vivo.

摘要

最近，咖啡成分 5-O-咖啡酰奎宁酸（CGA）和 N-甲基吡啶鎓（NMP）在细胞培养条件下被鉴定为诱导 Nrf2/抗氧化反应元件（ARE）解毒途径的物质。为了研究 CGA 和 NMP 对复杂咖啡饮料中 Nrf2 激活特性的影响，通过改变烘焙条件生成了两种不同的模型咖啡：一种是富含 CGA 的浅度烘焙咖啡，另一种是 CGA 含量低但含有高水平 NMP 的深度烘焙咖啡。体外和体内监测了 Nrf2/抗氧化反应元件途径的激活情况。

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