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普罗文奇:革命性技术还是道德败笔?

Provenge: revolutionary technology or ethical bust?

作者信息

Dickerson Justin B

机构信息

Department of Health Policy & Management; School of Rural Public Health; Texas A&M Health Science Center; College Station, TX, USA.

出版信息

Hum Vaccin. 2011 Apr;7(4):477-80. doi: 10.4161/hv.7.4.14189. Epub 2011 Apr 1.

DOI:10.4161/hv.7.4.14189
PMID:21451262
Abstract

Sipuleucel-T (known by the trade name, "Provenge") is the first prostate cancer vaccine approved by the Food and Drug Administration (FDA), and represents a new type of cancer therapy termed, Autologous Cellular Immunotherapy (ACT). This therapy has been described as a revolution in technology by clinicians and researchers alike. However, policy-makers and health economists question the efficacy of such treatment given its costs, while mainstream media often bemoan Provenge as yet another example of a healthcare system gone awry. This paper examines the debate for and against Provenge, and discusses why Medicare adoption of payment protocols for the vaccine may violate the egalitarian and feminist principles of distributive justice theory. The paper also acknowledges the larger context of the Provenge debate within the bioethical community; that is, how much should society be willing to invest to prevent death? The paper concludes by arguing for a more thorough ethical review of such new technologies by policy-makers prior to the adoption of funding protocols.

摘要

西普尼克- T(商品名为“普列威”)是美国食品药品监督管理局(FDA)批准的首款前列腺癌疫苗,代表了一种名为自体细胞免疫疗法(ACT)的新型癌症治疗方法。临床医生和研究人员都将这种疗法描述为技术上的一场革命。然而,政策制定者和健康经济学家鉴于其成本对这种治疗方法的疗效提出质疑,而主流媒体经常哀叹普列威是医疗保健系统出问题的又一个例子。本文审视了支持和反对普列威的争论,并讨论了医疗保险采用该疫苗支付方案为何可能违反分配正义理论的平等主义和女权主义原则。本文还承认了生物伦理学界关于普列威争论的更大背景;也就是说,社会应该愿意投入多少来预防死亡?本文最后主张政策制定者在采用资助方案之前,对这类新技术进行更全面的伦理审查。

相似文献

1
Provenge: revolutionary technology or ethical bust?普罗文奇:革命性技术还是道德败笔?
Hum Vaccin. 2011 Apr;7(4):477-80. doi: 10.4161/hv.7.4.14189. Epub 2011 Apr 1.
2
Sipuleucel-T (Provenge): immunotherapy for metastatic prostate cancer.西普列尤斯-T(普罗文奇):转移性前列腺癌的免疫疗法。
Urol Nurs. 2012 Mar-Apr;32(2):95-8.
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Sipuleucel-T (Provenge®) for castration-resistant prostate cancer.注射用前列腺酸性磷酸酶疫苗(Provenge®)治疗去势抵抗性前列腺癌。
BJU Int. 2012 Jul;110(2 Pt 2):E99-104. doi: 10.1111/j.1464-410X.2011.10790.x. Epub 2011 Dec 16.
4
Sipuleucel-T immunotherapy for castration-resistant prostate cancer.用于去势抵抗性前列腺癌的西妥昔单抗-T免疫疗法。
N Engl J Med. 2010 Nov 11;363(20):1966-7; author reply 1968. doi: 10.1056/NEJMc1009982.
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Listening to Provenge--what a costly cancer treatment says about future Medicare policy.聆听“普罗文奇”——一种昂贵的癌症治疗方法对未来医疗保险政策的启示。
N Engl J Med. 2011 May 5;364(18):1687-9. doi: 10.1056/NEJMp1103057. Epub 2011 Apr 6.
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Sipuleucel-T (Provenge): active cellular immunotherapy for advanced prostate cancer.西普列尤斯-T(普罗文奇):用于晚期前列腺癌的活性细胞免疫疗法。
Issues Emerg Health Technol. 2007 Sep(101):1-4.
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Therapeutic cancer vaccine survives biotech bust.治疗性癌症疫苗在生物技术泡沫破裂后存活下来。
Nature. 2015 Mar 5;519(7541):17-8. doi: 10.1038/nature.2015.16990.
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New treatments for metastic prostate cancer.转移性前列腺癌的新疗法。
Med Lett Drugs Ther. 2010 Sep 6;52(1346):69-70.
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Sipuleucel-T for the treatment of metastatic prostate cancer: promise and challenges.Sipuleucel-T 治疗转移性前列腺癌:前景与挑战。
Hum Vaccin Immunother. 2012 Apr;8(4):509-19. doi: 10.4161/hv.18860. Epub 2012 Apr 1.
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Sipuleucel-T: APC 8015, APC-8015, prostate cancer vaccine--Dendreon.西普列尤斯-T:APC 8015、APC - 8015、前列腺癌疫苗——丹德昂公司
Drugs R D. 2006;7(3):197-201. doi: 10.2165/00126839-200607030-00006.

引用本文的文献

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Dendritic cell hybrid nanovaccine for mild heat inspired cancer immunotherapy.基于温和热刺激的树突细胞杂交纳米疫苗用于癌症免疫治疗。
J Nanobiotechnology. 2023 Sep 26;21(1):347. doi: 10.1186/s12951-023-02106-8.
2
Prostate Cancer Immunotherapy: Exploiting the HLA Class II Pathway in Vaccine Design.前列腺癌免疫疗法:在疫苗设计中利用HLA II类途径
J Clin Cell Immunol. 2015 Aug;6(4). doi: 10.4172/2155-9899.1000351. Epub 2015 Aug 26.
3
Vaccines and global health.疫苗与全球健康。
Philos Trans R Soc Lond B Biol Sci. 2011 Oct 12;366(1579):2733-42. doi: 10.1098/rstb.2011.0076.