Tanida Mamoru, Mori Masatomo
Department of Biomedical Sciences, College of Life Sciences, Ritsumeikan University, Kusatsu, Shiga, Japan.
Neuroreport. 2011 Apr 20;22(6):309-12. doi: 10.1097/WNR.0b013e328346107f.
Earlier examination reported that central injection of nesfatin-1 elevated blood pressure and suppressed food intake in conscious rats. In this study, we analyzed the effects of the intracerebroventricular injection of nesfatin-1 on the sympathetic nerve outflow to the kidney in urethane-anesthetized rats. An intracerebroventricular injection of nesfatin-1 significantly stimulated renal sympathetic nerve activity and blood pressure in a dose-dependent manner. Moreover, we examined the role of the melanocortin system on the sympathoexcitation caused by the nesfatin-1 injection. Pretreatment with the melanocortin-3/4 receptor antagonist, SHU9119, abolished the increase in nerve activity and blood pressure induced by nesfatin-1. Thus, the stimulating effects of nesfatin-1 administration on the sympathetic nerve activity of the kidney may depend on the central melanocortin system.
早期研究报告称，向清醒大鼠脑室内注射nesfatin-1可升高血压并抑制食物摄入。在本研究中，我们分析了向乌拉坦麻醉的大鼠脑室内注射nesfatin-1对肾交感神经传出的影响。向脑室内注射nesfatin-1以剂量依赖的方式显著刺激肾交感神经活动和血压。此外，我们研究了黑皮质素系统在nesfatin-1注射引起的交感兴奋中的作用。用黑皮质素-3/4受体拮抗剂SHU9119预处理可消除nesfatin-1诱导的神经活动和血压升高。因此，给予nesfatin-1对肾交感神经活动的刺激作用可能依赖于中枢黑皮质素系统。
