School of Mechanical and Aerospace Engineering, Nanyang Technological University, 50 Nanyang Avenue, 639798, Singapore.
Chem Commun (Camb). 2011 May 14;47(18):5235-7. doi: 10.1039/c1cc00075f. Epub 2011 Mar 30.
Carbon nanomaterials such as multiwalled carbon nanotubes (MWCNTs) and graphene oxide (GO) have been functionalized by highly hydrophilic and biocompatible poly(vinyl alcohol) (PVA) for loading and delivery of an anticancer drug, camptothecin (CPT). For the first time, CPT was loaded onto MWCNT-PVA and GO-PVA through π-π interactions and its capability to kill human breast and skin cancer cells was investigated.
碳纳米材料，如多壁碳纳米管 (MWCNTs) 和氧化石墨烯 (GO)，已通过高亲水性和生物相容性的聚乙烯醇 (PVA) 进行功能化，用于负载和输送抗癌药物喜树碱 (CPT)。CPT 首次通过 π-π 相互作用被负载到 MWCNT-PVA 和 GO-PVA 上，并研究了其杀死人类乳腺癌和皮肤癌细胞的能力。
