树突状细胞作为诱导移植耐受的工具：障碍与机遇。
Dendritic cells as a tool to induce transplantation tolerance: obstacles and opportunities.
机构信息
Department of Nephrology, Leiden University Medical Center, Leiden, The Netherlands.
出版信息
Transplantation. 2011 Jan 15;91(1):2-7. doi: 10.1097/tp.0b013e31820263b3.
PMID:21452405
Abstract
Dendritic cells are the key component to regulate and coordinate adaptive immune responses, including tolerance. This overview will briefly summarize different strategies to generate tolerogenic dendritic cell and the in vivo use of these cells in experimental transplantation models. We discuss some obstacles and possible solutions including alternative strategies for the use of negative vaccination in the context of organ transplantation.
摘要
树突状细胞是调节和协调适应性免疫反应的关键组成部分，包括耐受。这篇综述将简要总结生成耐受树突状细胞的不同策略，以及这些细胞在实验性移植模型中的体内应用。我们讨论了一些障碍和可能的解决方案，包括在器官移植背景下使用负疫苗接种的替代策略。
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