• 文献检索
  • 文档翻译
  • 深度研究
  • 学术资讯
  • Suppr Zotero 插件Zotero 插件
  • 邀请有礼
  • 套餐&价格
  • 历史记录
应用&插件
Suppr Zotero 插件Zotero 插件浏览器插件Mac 客户端Windows 客户端微信小程序
定价
高级版会员购买积分包购买API积分包
服务
文献检索文档翻译深度研究API 文档MCP 服务
关于我们
关于 Suppr公司介绍联系我们用户协议隐私条款
关注我们

Suppr 超能文献

核心技术专利:CN118964589B侵权必究
粤ICP备2023148730 号-1Suppr @ 2026

文献检索

告别复杂PubMed语法,用中文像聊天一样搜索,搜遍4000万医学文献。AI智能推荐,让科研检索更轻松。

立即免费搜索

文件翻译

保留排版,准确专业,支持PDF/Word/PPT等文件格式,支持 12+语言互译。

免费翻译文档

深度研究

AI帮你快速写综述,25分钟生成高质量综述,智能提取关键信息,辅助科研写作。

立即免费体验

儿童类风湿性紫癜:一项回顾性研究

Rheumatoid Purpura in Children: A Retrospective Study.

作者信息

Boudarbala Hajar, Elouali Aziza, Sara Anane, Rkain Maria, Babakhouya Abdeladim

机构信息

Department of Pediatrics and Child Health, Mohammed VI University Hospital, Oujda, MAR.

Faculty of Medicine and Pharmacy, Mohammed I University, Centre Hospitalier Universitaire (CHU) Mohammed VI, Oujda, MAR.

出版信息

Cureus. 2024 Nov 11;16(11):e73443. doi: 10.7759/cureus.73443. eCollection 2024 Nov.

DOI:10.7759/cureus.73443
PMID:39669869
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC11634565/
Abstract

Introduction Rheumatoid purpura, also referred to as Schönlein-Henoch disease, is a form of systemic vasculitis that is characterized by the presence of IgA deposits within the walls of small vessels. The primary symptoms include skin purpura, arthralgia, abdominal discomfort, and urinary tract abnormalities. While often benign, the disease can result in severe complications, particularly those affecting the digestive and renal systems, which require urgent medical attention. Objectives This study aims to analyze the epidemiological, clinical, biological, therapeutic, and evolutionary characteristics of rheumatoid purpura in order to enhance understanding of its clinical and therapeutic management. The aim is to expand knowledge of the disease and optimize treatment strategies to prevent serious complications. Methods and results This retrospective study encompasses 39 cases of rheumatoid purpura treated at the General Pediatrics Department of CHU Mohamed VI in Oujda, Morocco, over a period of nine years and six months from January 2015 to June 2024. The patients had a mean age of 6.5 years, and there was a marked male predominance (sex ratio of 2.57). All patients exhibited cutaneous purpura (100%). Approximately 75% of patients exhibited joint involvement, 89% of cases were associated with digestive manifestations, and 28% of cases demonstrated renal involvement. Conclusion Rheumatoid purpura is a pediatric condition often triggered by an upper respiratory infection, characterized by IgA deposits. While typically benign, it can lead to severe complications, particularly in the digestive and renal systems. Corticosteroids are key in managing acute cases, although their preventive efficacy is limited. Early and appropriate management is crucial for improving long-term outcomes.

摘要

引言

类风湿性紫癜,也称为许兰 - 亨诺氏病,是一种系统性血管炎,其特征是小血管壁内存在IgA沉积。主要症状包括皮肤紫癜、关节痛、腹部不适和泌尿系统异常。虽然该疾病通常为良性,但可能导致严重并发症,尤其是影响消化和肾脏系统的并发症,需要紧急医疗关注。

目的

本研究旨在分析类风湿性紫癜的流行病学、临床、生物学、治疗和演变特征,以增进对其临床和治疗管理的理解。目的是扩展对该疾病的认识并优化治疗策略以预防严重并发症。

方法与结果

这项回顾性研究涵盖了2015年1月至2024年6月在摩洛哥乌季达穆罕默德六世大学医院儿科普通病房接受治疗的39例类风湿性紫癜病例。患者的平均年龄为6.5岁,男性明显居多(性别比为2.57)。所有患者均出现皮肤紫癜(100%)。约75%的患者有关节受累,89%的病例伴有消化系统表现,28%的病例有肾脏受累。

结论

类风湿性紫癜是一种常由上呼吸道感染引发的儿科疾病,其特征为IgA沉积。虽然通常为良性,但可能导致严重并发症,尤其是在消化和肾脏系统。皮质类固醇在急性病例的管理中至关重要,尽管其预防效果有限。早期和适当的管理对于改善长期预后至关重要。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7453/11634565/fd9f0dd81285/cureus-0016-00000073443-i02.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7453/11634565/9c603270d3df/cureus-0016-00000073443-i01.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7453/11634565/fd9f0dd81285/cureus-0016-00000073443-i02.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7453/11634565/9c603270d3df/cureus-0016-00000073443-i01.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7453/11634565/fd9f0dd81285/cureus-0016-00000073443-i02.jpg

相似文献

1
Rheumatoid Purpura in Children: A Retrospective Study.儿童类风湿性紫癜:一项回顾性研究
Cureus. 2024 Nov 11;16(11):e73443. doi: 10.7759/cureus.73443. eCollection 2024 Nov.
2
Henoch-Schönlein Purpura in Children: An Updated Review.儿童过敏性紫癜:最新综述。
Curr Pediatr Rev. 2020;16(4):265-276. doi: 10.2174/1573396316666200508104708.
3
Lumbar swelling and migrating edema in 3- and 4-year-old boys.3岁和4岁男孩的腰部肿胀及游走性水肿。
SAGE Open Med Case Rep. 2022 May 25;10:2050313X221102112. doi: 10.1177/2050313X221102112. eCollection 2022.
4
Henoch-Schönlein purpura with acute pancreatitis: analysis of 13 cases.过敏性紫癜合并急性胰腺炎 13 例分析
BMC Pediatr. 2018 May 11;18(1):159. doi: 10.1186/s12887-018-1142-7.
5
Risk factors for renal involvement in Henoch-Schönlein purpura.过敏性紫癜性肾炎的发病危险因素。
J Pediatr (Rio J). 2021 Nov-Dec;97(6):646-650. doi: 10.1016/j.jped.2021.01.008. Epub 2021 Mar 12.
6
Henoch-Schönlein purpura: clinicopathologic correlation of cutaneous vascular IgA deposits and the relationship to leukocytoclastic vasculitis.过敏性紫癜:皮肤血管IgA沉积的临床病理相关性及其与白细胞破碎性血管炎的关系
Acta Derm Venereol. 1995 Mar;75(2):125-9. doi: 10.2340/0001555575125129.
7
A Review of IgA Vasculitis (Henoch-Schönlein Purpura) Past, Present, and Future.IgA血管炎(过敏性紫癜)的回顾:过去、现在与未来
Med Sci Monit. 2024 Jan 28;30:e943912. doi: 10.12659/MSM.943912.
8
IgA vasculitis (Henoch-Shönlein purpura) in adults: Diagnostic and therapeutic aspects.成人 IgA 血管炎(过敏性紫癜):诊断与治疗方面。
Autoimmun Rev. 2015 Jul;14(7):579-85. doi: 10.1016/j.autrev.2015.02.003. Epub 2015 Feb 14.
9
[Adult IgA vasculitis (Henoch-Schönlein purpura)].[成人IgA血管炎(过敏性紫癜)]
Nephrol Ther. 2019 Apr;15 Suppl 1:S13-S20. doi: 10.1016/j.nephro.2019.02.001.
10
"Joining the Spots in Adults and Young Tots": A Clinicopathological Study of Henoch-Schönlein Purpura (IgA Vasculitis).“连接成人和幼儿的斑点”:过敏性紫癜(IgA 血管炎)的临床病理研究
Am J Dermatopathol. 2017 Aug;39(8):587-592. doi: 10.1097/DAD.0000000000000761.

引用本文的文献

1
Exploring the shared molecular mechanisms of primary hypertension and IgA vasculitis through a case report and combining bioinformatics analysis.通过病例报告并结合生物信息学分析探索原发性高血压和IgA血管炎的共同分子机制。
Front Immunol. 2025 Jun 6;16:1596174. doi: 10.3389/fimmu.2025.1596174. eCollection 2025.

本文引用的文献

1
Henoch-Schönlein purpura in children: limited benefit of corticosteroids.儿童过敏性紫癜:皮质类固醇的疗效有限。
Can Fam Physician. 2014 Nov;60(11):1007-10.
2
Henoch Schonlein Purpura in children: clinical analysis of 120 cases.儿童过敏性紫癜:120例临床分析
Afr Health Sci. 2013 Mar;13(1):94-9. doi: 10.4314/ahs.v13i1.26.
3
[Henoch-Schönlein Purpura a dual follow up between pediatrician and pediatric nephrologist].[过敏性紫癜:儿科医生与儿科肾病专家的双重随访]
Rev Med Suisse. 2011 Feb 23;7(283):442-6.
4
Clinical outcomes in children with Henoch-Schönlein purpura nephritis grade IIIa or IIIb.儿童过敏性紫癜肾炎 3a 级或 3b 级的临床转归。
Pediatr Nephrol. 2011 Jul;26(7):1083-8. doi: 10.1007/s00467-011-1834-9. Epub 2011 Mar 9.
5
Diagnosis of Henoch-Schonlein purpura in a child presenting with bilateral acute scrotum.
Acta Biomed. 2009;80(3):289-91.
6
Predictors of outcome in Henoch-Schönlein nephritis.过敏性紫癜性肾炎的预后预测因素。
Pediatr Nephrol. 2010 Jun;25(6):1101-8. doi: 10.1007/s00467-010-1444-y. Epub 2010 Feb 20.
7
[Kidney and vaculitis in children].
Arch Pediatr. 2009 Jun;16(6):529-31. doi: 10.1016/S0929-693X(09)74055-2.
8
[Henoch-Shönlein purpura].[过敏性紫癜]
Nephrol Ther. 2009 Dec;5(7):663-75. doi: 10.1016/j.nephro.2009.02.001. Epub 2009 Apr 2.
9
[Hypertension in the absence of renal involvement during childhood Henoch-Schönlein purpura].[儿童过敏性紫癜无肾脏受累时的高血压]
Arch Pediatr. 2008 Jul;15(7):1193-6. doi: 10.1016/j.arcped.2008.04.003. Epub 2008 May 27.
10
Clinical update: Henoch-Schönlein purpura.临床最新进展:过敏性紫癜
Lancet. 2007 Mar 24;369(9566):976-8. doi: 10.1016/S0140-6736(07)60474-7.