Boudarbala Hajar, Elouali Aziza, Sara Anane, Rkain Maria, Babakhouya Abdeladim
Department of Pediatrics and Child Health, Mohammed VI University Hospital, Oujda, MAR.
Faculty of Medicine and Pharmacy, Mohammed I University, Centre Hospitalier Universitaire (CHU) Mohammed VI, Oujda, MAR.
Cureus. 2024 Nov 11;16(11):e73443. doi: 10.7759/cureus.73443. eCollection 2024 Nov.
Introduction Rheumatoid purpura, also referred to as Schönlein-Henoch disease, is a form of systemic vasculitis that is characterized by the presence of IgA deposits within the walls of small vessels. The primary symptoms include skin purpura, arthralgia, abdominal discomfort, and urinary tract abnormalities. While often benign, the disease can result in severe complications, particularly those affecting the digestive and renal systems, which require urgent medical attention. Objectives This study aims to analyze the epidemiological, clinical, biological, therapeutic, and evolutionary characteristics of rheumatoid purpura in order to enhance understanding of its clinical and therapeutic management. The aim is to expand knowledge of the disease and optimize treatment strategies to prevent serious complications. Methods and results This retrospective study encompasses 39 cases of rheumatoid purpura treated at the General Pediatrics Department of CHU Mohamed VI in Oujda, Morocco, over a period of nine years and six months from January 2015 to June 2024. The patients had a mean age of 6.5 years, and there was a marked male predominance (sex ratio of 2.57). All patients exhibited cutaneous purpura (100%). Approximately 75% of patients exhibited joint involvement, 89% of cases were associated with digestive manifestations, and 28% of cases demonstrated renal involvement. Conclusion Rheumatoid purpura is a pediatric condition often triggered by an upper respiratory infection, characterized by IgA deposits. While typically benign, it can lead to severe complications, particularly in the digestive and renal systems. Corticosteroids are key in managing acute cases, although their preventive efficacy is limited. Early and appropriate management is crucial for improving long-term outcomes.
引言
类风湿性紫癜,也称为许兰 - 亨诺氏病,是一种系统性血管炎,其特征是小血管壁内存在IgA沉积。主要症状包括皮肤紫癜、关节痛、腹部不适和泌尿系统异常。虽然该疾病通常为良性,但可能导致严重并发症,尤其是影响消化和肾脏系统的并发症,需要紧急医疗关注。
目的
本研究旨在分析类风湿性紫癜的流行病学、临床、生物学、治疗和演变特征,以增进对其临床和治疗管理的理解。目的是扩展对该疾病的认识并优化治疗策略以预防严重并发症。
方法与结果
这项回顾性研究涵盖了2015年1月至2024年6月在摩洛哥乌季达穆罕默德六世大学医院儿科普通病房接受治疗的39例类风湿性紫癜病例。患者的平均年龄为6.5岁,男性明显居多(性别比为2.57)。所有患者均出现皮肤紫癜(100%)。约75%的患者有关节受累,89%的病例伴有消化系统表现,28%的病例有肾脏受累。
结论
类风湿性紫癜是一种常由上呼吸道感染引发的儿科疾病,其特征为IgA沉积。虽然通常为良性,但可能导致严重并发症,尤其是在消化和肾脏系统。皮质类固醇在急性病例的管理中至关重要,尽管其预防效果有限。早期和适当的管理对于改善长期预后至关重要。