Cooper M A, Jin Y F, Ashby J P, Andrews J M, Wise R
Department of Medical Microbiology, Dudley Road Hospital, Birmingham, UK.
J Antimicrob Chemother. 1990 Aug;26(2):203-7. doi: 10.1093/jac/26.2.203.
The post-antibiotic effect (PAE) of teicoplanin was compared with that of vancomycin for five selected Gram-positive cocci. Two concentrations of each antibiotic were investigated, with the test organisms being exposed to each for both 1 and 2 h. At a concentration of 25 mg/l, teicoplanin had a greater PAE than vancomycin for the methicillin resistant staphylococci and Enterococcus faecalis strains tested. At a concentration of 5 mg/l, teicoplanin gave equal effects to those of vancomycin except for the strain of methicillin-resistant Staphylococcus aureus (MRSA) tested. The variation in the antibiotic exposure time gave only small changes in the PAE, except for the MRSA tested.
比较了替考拉宁和万古霉素对五种选定革兰氏阳性球菌的抗生素后效应（PAE）。研究了每种抗生素的两种浓度，将受试微生物分别暴露于这两种浓度下1小时和2小时。在25mg/l的浓度下，替考拉宁对所测试的耐甲氧西林葡萄球菌和粪肠球菌菌株的PAE比万古霉素更大。在5mg/l的浓度下，除了所测试的耐甲氧西林金黄色葡萄球菌（MRSA）菌株外，替考拉宁的效果与万古霉素相当。除了所测试的MRSA菌株外，抗生素暴露时间的变化仅使PAE发生微小变化。
