Bezian M C, Ribou G, Masquelier B
Laboratoire de Bactériologie, Hôpital Saint-André, Bordeaux, France.
Pathol Biol (Paris). 1992 May;40(5):461-5.
The activities of vancomycin and teicoplanin against 148 strains of Gram-positive cocci were tested using agar diffusion and liquid microdilution MIC determination. Tested strains included 84 staphylococci, 32 S. aureus, 52 coagulase-negative staphylococci (CNS), 52 enterococci, and 12 streptococci. Most strains (136) were susceptible to both agents, with inhibition diameters of 17 mm or more. MRSA strains exhibited lower geometric MIC means with teicoplanin (0.90 micrograms/ml) than with vancomycin (1.79 micrograms/ml); this difference was found for methicillin-susceptible S. aureus strains (1.07 and 1.38 micrograms/ml for teicoplanin and vancomycin, respectively). In contrast, methicillin-susceptible and methicillin-resistant strains of CNS exhibited similar MICs (1.60 micrograms/ml approximately). Enterococci were more susceptible to teicoplanin (MIC 0.25 micrograms/ml) than to vancomycin (MIC 1.35 micrograms/ml). Both vancomycin and teicoplanin were thus found to be consistently effective against Gram-positive cocci; however, teicoplanin proved more effective than vancomycin against enterococci and methicillin-resistant S. aureus strains and may therefore be a valuable therapeutic alternative for these multiresistant organisms.
采用琼脂扩散法和液体微量稀释法测定最低抑菌浓度（MIC），检测了万古霉素和替考拉宁对148株革兰氏阳性球菌的抗菌活性。受试菌株包括84株葡萄球菌、32株金黄色葡萄球菌、52株凝固酶阴性葡萄球菌（CNS）、52株肠球菌和12株链球菌。大多数菌株（136株）对这两种药物敏感，抑菌直径达17毫米或以上。耐甲氧西林金黄色葡萄球菌（MRSA）菌株对替考拉宁的几何平均MIC（0.90微克/毫升）低于万古霉素（1.79微克/毫升）；甲氧西林敏感金黄色葡萄球菌菌株也存在这种差异（替考拉宁和万古霉素的MIC分别为1.07和1.38微克/毫升）。相比之下，甲氧西林敏感和耐药的CNS菌株MIC相似（约1.60微克/毫升）。肠球菌对替考拉宁（MIC 0.25微克/毫升）比对万古霉素（MIC 1.35微克/毫升）更敏感。因此，万古霉素和替考拉宁对革兰氏阳性球菌均持续有效；然而，替考拉宁对肠球菌和耐甲氧西林金黄色葡萄球菌菌株比万古霉素更有效，因此对于这些多重耐药菌可能是一种有价值的治疗选择。
