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用于 CT 的光子计数 X 射线探测器性能建模:能量响应和脉冲堆积效应。

Modeling the performance of a photon counting x-ray detector for CT: energy response and pulse pileup effects.

机构信息

Division of Medical Imaging Physics, The Russell H. Morgan Department of Radiology and Radiological Science, Johns Hopkins University School of Medicine, Baltimore, Maryland 21287, USA.

出版信息

Med Phys. 2011 Feb;38(2):1089-102. doi: 10.1118/1.3539602.

Abstract

PURPOSE

Recently, photon counting x-ray detectors (PCXDs) with energy discrimination capabilities have been developed for potential use in clinical computed tomography (CT) scanners. These PCXDs have great potential to improve the quality of CT images due to the absence of electronic noise and weights applied to the counts and the additional spectral information. With high count rates encountered in clinical CT, however, coincident photons are recorded as one event with a higher or lower energy due to the finite speed of the PCXD. This phenomenon is called a "pulse pileup event" and results in both a loss of counts (called "deadtime losses") and distortion of the recorded energy spectrum. Even though the performance of PCXDs is being improved, it is essential to develop algorithmic methods based on accurate models of the properties of detectors to compensate for these effects. To date, only one PCXD (model DXMCT-1, DxRay, Inc., Northridge, CA) has been used for clinical CT studies. The aim of that study was to evaluate the agreement between data measured by DXMCT-1 and those predicted by analytical models for the energy response, the deadtime losses, and the distorted recorded spectrum caused by pulse pileup effects.

METHODS

An energy calibration was performed using 99mTc (140 keV), 57Co (122 keV), and an x-ray beam obtained with four x-ray tube voltages (35, 50, 65, and 80 kVp). The DXMCT-1 was placed 150 mm from the x-ray focal spot; the count rates and the spectra were recorded at various tube current values from 10 to 500 microA for a tube voltage of 80 kVp. Using these measurements, for each pulse height comparator we estimated three parameters describing the photon energy-pulse height curve, the detector deadtime tau, a coefficient k that relates the x-ray tube current I to an incident count rate a by a = k x I, and the incident spectrum. The mean pulse shape of all comparators was acquired in a separate study and was used in the model to estimate the distorted recorded spectrum. The agreement between data measured by the DXMCT-1 and those predicted by the models was quantified by the coefficient of variation (COV), i.e., the root mean square difference divided by the mean of the measurement.

RESULTS

Photon energy versus pulse height curves calculated with an analytical model and those measured using the DXMCT-1 were in agreement within 0.2% in terms of the COV. The COV between the output count rates measured and those predicted by analytical models was 2.5% for deadtime losses of up to 60%. The COVs between spectra measured and those predicted by the detector model were within 3.7%-7.2% with deadtime losses of 19%-46%.

CONCLUSIONS

It has been demonstrated that the performance of the DXMCT-1 agreed exceptionally well with the analytical models regarding the energy response, the count rate, and the recorded spectrum with pulse pileup effects. These models will be useful in developing methods to compensate for these effects in PCXD-based clinical CT systems.

摘要

目的

最近,具有能量分辨能力的光子计数 X 射线探测器(PCXD)已经开发出来,可能用于临床 CT 扫描仪。由于不存在电子噪声以及对计数的权重和附加光谱信息,这些 PCXD 具有极大地改善 CT 图像质量的潜力。然而,在临床 CT 中遇到高计数率时,由于 PCXD 的速度有限,会将符合的光子记录为一个具有更高或更低能量的事件。这种现象称为“脉冲堆积事件”,导致计数损失(称为“死时间损失”)和记录的能谱失真。尽管 PCXD 的性能正在得到改善,但必须开发基于探测器特性的准确模型的算法方法来补偿这些影响。迄今为止,只有一种 PCXD(型号 DXMCT-1,DxRay,Inc.,Northridge,CA)用于临床 CT 研究。该研究的目的是评估 DXMCT-1 测量的数据与分析模型预测的数据之间的一致性,该分析模型用于能量响应、死时间损失以及由脉冲堆积效应引起的记录光谱失真。

方法

使用 99mTc(140keV)、57Co(122keV)和四个 X 射线管电压(35、50、65 和 80kVp)获得的 X 射线束进行能量校准。将 DXMCT-1 放置在离 X 射线焦点 150mm 处;在管电压为 80kVp 时,以 10 至 500μA 的不同管电流值记录计数率和谱线。使用这些测量值,我们为每个脉冲高度比较器估计了三个参数,这些参数描述了光子能量-脉冲高度曲线、探测器死时间τ、一个系数 k,该系数通过 a=kxi 将 X 射线管电流 I 与入射计数率 a 相关联,以及入射光谱。所有比较器的平均脉冲形状在单独的研究中获得,并用于模型中以估计记录的失真谱线。通过变异系数(COV),即均方根差除以测量值的平均值,来量化 DXMCT-1 测量的数据与模型预测的数据之间的一致性。

结果

使用分析模型计算的光子能量与脉冲高度曲线与使用 DXMCT-1 测量的曲线之间的 COV 在 0.2%以内一致。对于高达 60%的死时间损失,输出计数率的测量值与分析模型预测值之间的 COV 为 2.5%。在死时间损失为 19%-46%时,测量谱线与探测器模型预测谱线之间的 COV 为 3.7%-7.2%。

结论

已经证明,DXMCT-1 的性能与分析模型在能量响应、计数率和具有脉冲堆积效应的记录光谱方面非常吻合。这些模型将有助于开发用于补偿基于 PCXD 的临床 CT 系统中这些影响的方法。

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