Southwest Center for Natural Products Research and Commercialization, School of Natural Resources and the Environment, College of Agriculture and Life Sciences, The University of Arizona, 250 E. Valencia Road, Tucson, Arizona 85706-6800, USA.
J Nat Prod. 2011 Apr 25;74(4):852-6. doi: 10.1021/np100763p. Epub 2011 Mar 31.
Bioassay-guided fractionation of a solid tumor selective extract of the leaves and twigs of Antheroporum pierrei acquired from the U.S. National Cancer Institute extract repository afforded four new pyranoisoflavones, pierreiones A-D (1-4), together with rotenone (5), 12a-hydroxyrotenone (6), and tephrosin (7). The structures of all new compounds were determined on the basis of their spectroscopic data, and the absolute configuration of 1 was assigned with the help of (1)H NMR analysis of its Mosher's ester derivatives. Compounds 1 and 5-7 accounted for the majority of the biological activity in terms of either cytotoxicity and/or selective toxicity to solid tumor cell lines. Pierreiones A (1) and B (2) demonstrated solid tumor selectivity with minimal cytotoxicity, while pierreione C (3) exhibited no activity.
生物测定导向的分离，从美国国立癌症研究所提取物库获得的Pierreae pierrei 的叶和小枝的固体肿瘤选择性提取物，得到了四个新的吡喃异黄酮，分别为 pierreiones A-D（1-4），以及鱼藤酮（5）、12a-羟基鱼藤酮（6）和瑞香素（7）。所有新化合物的结构都是根据它们的光谱数据确定的，并且 1 的绝对构型是通过对其 Mosher 酯衍生物的 1H NMR 分析来确定的。化合物 1 和 5-7 在细胞毒性和/或对固体肿瘤细胞系的选择性毒性方面表现出了大多数的生物活性。Pierreiones A（1）和 B（2）具有固体肿瘤选择性，细胞毒性最小，而 pierreione C（3）则没有活性。
