补骨脂中的细胞毒性成分。

Cytotoxic constituents from Psoralea corylifolia.

作者信息

Song Ping, Yang Xin-Zhou, Yuan Jing-Quan

机构信息

College of Chemistry and Life Sciences, Qinghai University for Nationalities, Xiling 810007, China.

出版信息

J Asian Nat Prod Res. 2013;15(6):624-30. doi: 10.1080/10286020.2013.793181. Epub 2013 May 10.

DOI:10.1080/10286020.2013.793181

PMID:23659434

Abstract

Bioassay directed isolation of the EtOAc extract from a traditional Chinese medicine Psoralea corylifolia resulted in the purification of two isoflavonoids, corylifols D (1) and E (2), along with four known ones. The structures of 1 and 2 were determined by extensive 1D and 2D NMR and MS data analyses. When tested against HepG2 and Hep3B hepatocellular carcinoma cell lines, corylifol A (4) displayed IC50 values of 4.6 and 13.5 μg/ml, respectively.

摘要

通过生物活性导向法从传统中药补骨脂中分离乙酸乙酯提取物，得到了两种异黄酮化合物补骨脂酚D（1）和补骨脂酚E（2），以及四种已知化合物。通过广泛的一维和二维核磁共振以及质谱数据分析确定了1和2的结构。在针对HepG2和Hep3B肝癌细胞系进行测试时，补骨脂酚A（4）的IC50值分别为4.6和13.5μg/ml。