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干血斑、药代动力学研究与更适合儿童的药物。

Dried blood spots, pharmacokinetic studies and better medicines for children.

作者信息

Pandya Hitesh C, Spooner Neil, Mulla Hussain

机构信息

Department of Infection, Immunity & Inflammation, University of Leicester, Robert Kilpatrick Clinical Sciences Building, Infirmary Square, Leicester, UK.

出版信息

Bioanalysis. 2011 Apr;3(7):779-86. doi: 10.4155/bio.11.19.

DOI:10.4155/bio.11.19
PMID:21452994
Abstract

Determining circulating drug concentrations in children is an ongoing obstacle to the development of age-appropriate dosing regimens. The requirement for small blood sample volumes in children compared with adults is a significant barrier to obtaining age-specific pharmacokinetic-pharmacodynamic data for this population and hence optimizing the efficacy and safety profile of medicines used by this group. This article discusses the potential for dried blood spot sampling to offer a solution to this issue.

摘要

确定儿童体内的循环药物浓度一直是制定适合其年龄的给药方案的障碍。与成人相比，儿童所需的血样量较小，这是为该人群获取特定年龄的药代动力学-药效学数据以及优化该群体所用药物的疗效和安全性概况的重大障碍。本文讨论了干血斑采样解决这一问题的潜力。

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