Department of Gastroenterology, Nagoya University Graduate School of Medicine, Nagoya, Japan.
BMC Gastroenterol. 2011 Mar 31;11:29. doi: 10.1186/1471-230X-11-29.
Real-time tissue sonoelastography (EG) is a new non-invasive technique that visualizes differences in tissue strain. We evaluated the usefulness of EG in patients with ulcerative colitis (UC) by investigating the association between EG and colonoscopic findings and disease activity.
Thirty-seven UC patients undergoing EG and colonoscopy were invited to enroll. EG findings were classified as normal, homogeneous, random, or hard, and colonoscopic findings as normal, mucosal edema and erosion, punched-out ulcer, and extensive mucosal abrasion. Clinical findings were evaluated using clinical activity index (CAI) scores for each patient at colonoscopy.
On EG, 10 cases were classified as normal, 11 as homogeneous, 6 as random, and 10 as hard. EG findings showed a significant correlation those of colonoscopy (p < 0.001). Seven of 10 (70%) normal-type patients were in the remission phase, while all 6 random-type patients were in the active phase. Among active-phase patients, 4 of 7 (57%) homogeneous-type patients responded to steroid or leukocytapheresis therapy, while 3 of 6 (50%) random-type patients required treatment with cyclosporine. Three of 10 (30%) hard-type patients required colectomy.
In this small series, EG findings reflected colonoscopic findings and correlated with disease activity among patients with UC.
实时组织超声弹性成像（EG）是一种新的非侵入性技术，可可视化组织应变的差异。我们通过研究 EG 与结肠镜检查结果和疾病活动之间的关系，评估 EG 在溃疡性结肠炎（UC）患者中的有用性。
邀请 37 名接受 EG 和结肠镜检查的 UC 患者参与研究。EG 结果分为正常、均匀、随机或坚硬，结肠镜检查结果分为正常、黏膜水肿和糜烂、穿孔性溃疡和广泛黏膜擦伤。每位患者在结肠镜检查时使用临床活动指数（CAI）评分评估临床发现。
在 EG 上，10 例分类为正常，11 例为均匀，6 例为随机，10 例为坚硬。EG 结果与结肠镜检查结果有显著相关性（p < 0.001）。10 例正常型患者中有 7 例（70%）处于缓解期，而所有 6 例随机型患者均处于活动期。在活动期患者中，7 例均匀型患者中有 4 例（57%）对类固醇或白细胞吸附治疗有反应，而 6 例随机型患者中有 3 例（50%）需要环孢素治疗。10 例坚硬型患者中有 3 例（30%）需要结肠切除术。
在这个小系列中，EG 结果反映了结肠镜检查结果，并与 UC 患者的疾病活动相关。
