Central Texas Veterans Health Care System, Temple, TX, USA.
Behav Brain Res. 2012 Feb 14;227(2):356-62. doi: 10.1016/j.bbr.2011.03.050. Epub 2011 Mar 29.
Neurogenesis occurs in the adult mammalian brain in discrete regions related to olfactory sensory signaling and integration. The olfactory receptor cell population is in constant turn-over through local progenitor cells. Also, newborn neurons are added to the olfactory bulbs through a major migratory route from the subventricular zone, the rostral migratory stream. The olfactory bulbs project to different brain structures, including: piriform cortex, amygdala, entorhinal cortex, striatum and hippocampus. These structures play important roles in odor identification, feeding behavior, social interactions, reproductive behavior, behavioral reinforcement, emotional responses, learning and memory. In all of these regions neurogenesis has been described in normal and in manipulated mammalian brain. These data are reviewed in the context of a sensory-behavioral hypothesis on adult neurogenesis that olfactory input modulates neurogenesis in many different regions of the brain.
神经发生发生在成年哺乳动物大脑中与嗅觉感觉信号和整合相关的离散区域。嗅觉受体细胞群体通过局部祖细胞不断更新。此外，通过从侧脑室到嗅球的主要迁移途径，新生神经元被添加到嗅球中，这个迁移途径称为前脑导水管周围灰质的迁移流。嗅球投射到不同的脑结构，包括：梨状皮层、杏仁核、内嗅皮层、纹状体和海马体。这些结构在气味识别、进食行为、社交互动、生殖行为、行为强化、情绪反应、学习和记忆中发挥重要作用。在正常和人为操作的哺乳动物大脑中，所有这些区域都描述了神经发生。在关于成年神经发生的感觉-行为假说的背景下，审查了这些数据，该假说认为嗅觉输入调节大脑中许多不同区域的神经发生。
