Department of Internal Medicine, Hospital Universitario Marqués de Valdecilla-IFIMAV, University of Cantabria, RETICEF, Santander, Spain.
Maturitas. 2011 Jun;69(2):162-7. doi: 10.1016/j.maturitas.2011.02.017. Epub 2011 Mar 31.
To compare bone parameters measured by calcaneous quantitative ultrasonography (BUS) in subjects with and without metabolic syndrome (MetS). In addition, we wanted to examine the association of each of the individual components of the syndrome with BUS measurements, to study the relationship between calciotropic hormones or bone turnover markers with BUS parameters in subjects with or without MetS, and to explore the possibility that the relationship between prevalent vertebral and non-vertebral fractures and BUS is influenced by MetS status.
Cross-sectional study.
We investigated 1209 (421 men and 788 women) participants from the Camargo Cohort Study. Prevalence of MetS was 27% in men and 31% in women. Women, but not men, with MetS had higher age-adjusted BUS parameters compared with those without (p<0.05), the difference disappearing after adjustment for BMI. Out of the five single components of MetS, only waist perimeter was significantly associated with BUS (p<0.01), the association being restricted to women. In men and women with MetS (but not without) a positive significant association was observed between BUS and 25OHD levels. BUS parameters were associated with serum P1NP or CTX in normal women, but not in those with MetS. Prevalent vertebral and non-vertebral fractures and BUS parameters (BUA and SOS, respectively) are inversely associated, but this relationship, however, is not influenced by MetS status.
BUS parameters are higher in women with MetS, and this difference disappears after adjusting for BMI. MetS status did not influence the relationship between BUS parameters and vertebral or non-vertebral fractures.
比较患有和不患有代谢综合征（MetS）的受试者的跟骨定量超声（BUS）测量的骨参数。此外，我们还希望检查综合征的每个单独成分与 BUS 测量值的关联，研究患有或不患有 MetS 的受试者的钙调节激素或骨转换标志物与 BUS 参数之间的关系，并探讨代谢综合征状态对普遍存在的椎体和非椎体骨折与 BUS 之间的关系的影响的可能性。
横断面研究。
我们调查了来自卡马戈队列研究的 1209 名（421 名男性和 788 名女性）参与者。男性中代谢综合征的患病率为 27%，女性中为 31%。与无代谢综合征的患者相比，患有代谢综合征的女性（而非男性）具有更高的年龄调整后 BUS 参数（p<0.05），但在调整 BMI 后差异消失。在代谢综合征的五个单一成分中，只有腰围与 BUS 显著相关（p<0.01），这种关联仅限于女性。在患有代谢综合征的男性和女性中（但在没有代谢综合征的患者中没有），BUS 与 25OHD 水平之间存在正相关关系。在正常女性中，BUS 参数与血清 P1NP 或 CTX 相关，但在患有代谢综合征的女性中则没有。普遍存在的椎体和非椎体骨折与 BUS 参数（BUA 和 SOS，分别）呈负相关，但这种关系不受代谢综合征状态的影响。
患有代谢综合征的女性的 BUS 参数较高，且在调整 BMI 后，这种差异消失。代谢综合征状态并不影响 BUS 参数与椎体或非椎体骨折之间的关系。
