Takemura G, Fujiwara H, Yoshida H, Mukoyama M, Saito Y, Nakao K, Fujiwara T, Uegaito T, Imura H, Kawai C
Department of Internal Medicine, Faculty of Medicine, Kyoto University, Japan.
J Pathol. 1990 Aug;161(4):285-92. doi: 10.1002/path.1711610404.
The expression of atrial natriuretic polypeptide (ANP) in the ventricles of human hearts with myocardial infarction (MI) was studied immunohistochemically. Immunoreactive myocytes were identified in the ventricular tissues of all of 16 hearts with old MI (both with and without heart failure) and in all five hearts with subacute MI, but not in any of the eight hearts without MI nor in the five with acute MI. In the nonfailing hearts with MI, ANP positive myocytes surrounded the areas of infarction, and were also seen in the subendocardium of the infarcted segment. In the failing hearts with MI, ANP expression was noted in the whole ventricular subendocardial region, in addition to the border of infarcts. The sites of ANP expression corresponded well to those of marked stress attributable to tissue shrinkage or fibrosis due to MI, haemodynamic overload, or both. It thus appears that ANP expression is augmented in human hearts with MI regardless of the presence or absence of heart failure, and it is suggested that regional mechanical stress on the ventricular myocardium, as well as haemodynamic overload, may be very closely associated with ventricular ANP expression.
采用免疫组织化学方法研究了心肌梗死（MI）患者心脏心室中的心钠素（ANP）表达情况。在16例陈旧性心肌梗死患者（伴或不伴心力衰竭）的所有心室组织以及5例亚急性心肌梗死患者的所有心脏心室组织中均鉴定出免疫反应性心肌细胞，但在8例无心肌梗死患者的心脏以及5例急性心肌梗死患者的心脏中均未发现。在无心力衰竭的心肌梗死患者心脏中，ANP阳性心肌细胞围绕梗死区域，在梗死节段的心内膜下也可见到。在有心力衰竭的心肌梗死患者心脏中，除梗死边界外，整个心室心内膜下区域均有ANP表达。ANP表达部位与因心肌梗死、血流动力学负荷过重或两者导致的组织收缩或纤维化引起的明显应激部位高度吻合。因此，无论有无心力衰竭，心肌梗死患者心脏中ANP表达均会增强，提示心室心肌的局部机械应力以及血流动力学负荷过重可能与心室ANP表达密切相关。
