Department of Nephrology, Zonguldak Atatürk State Hospital, Turkey.
J Ren Nutr. 2011 Nov;21(6):472-8. doi: 10.1053/j.jrn.2010.12.003. Epub 2011 Mar 31.
We analyzed the relationships between body mass index (BMI), waist circumference (WC), waist-to-hip ratio, and conicity index and 24-hour urinary albumin excretion rate (UAER) and creatinine clearance.
Cross-sectional study.
Patients presenting to a state hospital.
Study involved patients with type 2 diabetes.
Study participants underwent medical history examination, measurement of office blood pressure (BP), measurement of anthropometric factors and calculations (including BMI, WC, waist-to-hip ratio, and conicity index), physical examination, biochemical analysis, and 24-hour urine specimen collection to determine creatinine clearance and UAER.
In all, 202 patients with type 2 diabetes (male/female: 91/111, aged: 58.4 ± 10.1 years) were included. It was found that 24-hour UAER correlated with WC (rho: +0.176, P = .012), serum albumin (rho: -0.324, P < .0001), and systolic BP (rho: +0.153, P = .029), whereas creatinine clearance correlated with age (rho: -0.152, P = .031), BMI (rho: +0.191, P = .007), albumin level (rho: +0.365, P < .0001), and uric acid level (rho: -0.369, P < .0001). The stepwise linear regression analysis revealed that WC (P = .012), glycosylated hemoglobin (P = .018), and systolic BP (P = .043) were found to be independently related to logarithmically converted 24-hour UAER, whereas creatinine clearance was found to be related to duration of diabetes (P = .001), BMI (P = .008), presence of peripheral arterial disease (P = .021), fasting serum glucose level (P = .003), and uric acid level (P < .0001). However, after correction for body surface area, BMI was no longer associated with creatinine clearance.
Among the anthropometric parameters, only an increase in WC was found to be independently related to 24-hour UAER. Although BMI was associated with creatinine clearance, this association was lost after creatinine clearance was corrected for body surface area.
我们分析了体重指数（BMI）、腰围（WC）、腰臀比和锥形指数与 24 小时尿白蛋白排泄率（UAER）和肌酐清除率的关系。
横断面研究。
患者就诊于州立医院。
研究对象为 2 型糖尿病患者。
研究参与者接受病史检查、诊室血压测量、人体测量因素和计算（包括 BMI、WC、腰臀比和锥形指数）、体格检查、生化分析和 24 小时尿液标本采集，以确定肌酐清除率和 UAER。
共纳入 202 例 2 型糖尿病患者（男/女：91/111，年龄：58.4±10.1 岁）。结果发现，24 小时 UAER 与 WC（rho：+0.176，P=0.012）、血清白蛋白（rho：-0.324，P<0.0001）和收缩压（rho：+0.153，P=0.029）相关，而肌酐清除率与年龄（rho：-0.152，P=0.031）、BMI（rho：+0.191，P=0.007）、白蛋白水平（rho：+0.365，P<0.0001）和尿酸水平（rho：-0.369，P<0.0001）相关。逐步线性回归分析显示，WC（P=0.012）、糖化血红蛋白（P=0.018）和收缩压（P=0.043）与对数转换后 24 小时 UAER 独立相关，而肌酐清除率与糖尿病病程（P=0.001）、BMI（P=0.008）、外周动脉疾病（P=0.021）、空腹血糖水平（P=0.003）和尿酸水平（P<0.0001）相关。然而，校正体表面积后，BMI 与肌酐清除率不再相关。
在人体测量参数中，仅 WC 增加与 24 小时 UAER 独立相关。虽然 BMI 与肌酐清除率相关，但在肌酐清除率校正体表面积后，这种相关性消失。
