[HLA相关的扩张型心肌病易感性]

[HLA-associated predisposition to dilated cardiomyopathy].

作者信息

Polianskaia I S, Alekseev L P, Chumburidze V B, Iurenev A P, Guniia M G, Dubov P B, Dolbin A G

出版信息

Klin Med (Mosk). 1990 Jun;68(6):30-3.

Abstract

HLA-antigens grade I and II were studied by tissue typing in 60 Russians and 40 Georgians suffering from dilated cardiomyopathy (DCMP), and 40 Georgians with virus myocarditis. 267 test-donors Russians and 579 Georgians served as control. Markers of DCMP predisposition were found different for Russians and Georgians: DR4 (relative risk 2.96) and A11 (RR = 3.07), R12 (RR = 5.5), respectively. Georgians have a marker of resistance to DCMP--B35 (RR = 0.15). Antigen B12 marks a severe DCMP course in Georgians. Markers of virus myocarditis predisposition were distinct from those of DCMP: A1 (RR = 3.78) and B27 (RR = 3.62). This shows different etiology of the two diseases. The conclusion is made on nonidentical genetic markers of predisposition and resistance to the same disease in various populations.

摘要

通过组织分型对60名患有扩张型心肌病（DCMP）的俄罗斯人和40名格鲁吉亚人以及40名患有病毒性心肌炎的格鲁吉亚人进行了I级和II级HLA抗原研究。267名俄罗斯测试供体和579名格鲁吉亚人作为对照。发现俄罗斯人和格鲁吉亚人患DCMP的易感性标志物不同：分别为DR4（相对风险2.96）和A11（RR = 3.07）、R12（RR = 5.5）。格鲁吉亚人有一种对DCMP的抗性标志物——B35（RR = 0.15）。抗原B12标志着格鲁吉亚人DCMP病程严重。病毒性心肌炎的易感性标志物与DCMP不同：A1（RR = 3.78）和B27（RR = 3.62）。这表明这两种疾病的病因不同。得出的结论是，不同人群对同一种疾病的易感性和抗性的遗传标志物不同。