Popovici M, Groppa L, Kalinina L
Research Institute of Preventive and Clinical Medicine, Chisinau, Republic of Moldova.
Blood Press Suppl. 1996;3:49-52.
This work deals with the investigation of the HLA system antigen, classes A, B, CW and DR, in 100 patients with dilated cardiomyopathy and 200 healthy donors. It was shown that the HLA system antigen is involved in the hereditary predisposition to dilated cardiomyopathy and in its clinical polymorphism determination. The HLA system antigen distribution in patients with dilated cardiomyopathy clearly differs from the same index in the general population following this medical examination. The direct connection between the dilated cardiomyopathy and the HLA DQA1 gene confirms the hypothesis on the genetic determinism of this disease.
这项研究对100例扩张型心肌病患者和200名健康供者的HLA系统抗原A、B、CW和DR类进行了调查。结果表明，HLA系统抗原参与了扩张型心肌病的遗传易感性及其临床多态性的决定。经过此次医学检查，扩张型心肌病患者的HLA系统抗原分布与普通人群的相同指标明显不同。扩张型心肌病与HLA DQA1基因之间的直接联系证实了该疾病遗传决定论的假设。
