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HLA antigens in idiopathic dilated cardiomyopathy.特发性扩张型心肌病中的人类白细胞抗原
Br Heart J. 1989 Nov;62(5):379-83. doi: 10.1136/hrt.62.5.379.
2
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3
[HLA antigens in patients with primary cardiomyopathy].[原发性心肌病患者的人类白细胞抗原（HLA）抗原]
Kardiol Pol. 1988;31(9):598-604.
4
Association between HLA antigens and early onset periodontitis.
J Clin Periodontol. 1996 Jun;23(6):563-6. doi: 10.1111/j.1600-051x.1996.tb01825.x.
5
HLA antigen frequencies in end-stage idiopathic and ischaemic cardiomyopathy.终末期特发性和缺血性心肌病中的HLA抗原频率。
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[HLA-associated predisposition to dilated cardiomyopathy].[HLA相关的扩张型心肌病易感性]
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7
Antigens of the major histocompatibility system in ischemic heart disease and idiopathic dilated cardiomyopathy.缺血性心脏病和特发性扩张型心肌病中主要组织相容性系统的抗原
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Idiopathic dilated cardiomyopathy: familial prevalence and HLA distribution.特发性扩张型心肌病：家族患病率与HLA分布
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Do specific HLA antigens predispose to ischaemic heart disease or idiopathic dilated cardiomyopathy?特定的人类白细胞抗原（HLA）抗原是否易患缺血性心脏病或特发性扩张型心肌病？
Br Heart J. 1994 Jan;71(1):76-8. doi: 10.1136/hrt.71.1.76.

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Antigens of the major histocompatibility system in ischemic heart disease and idiopathic dilated cardiomyopathy.缺血性心脏病和特发性扩张型心肌病中主要组织相容性系统的抗原
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8
Idiopathic dilated cardiomyopathy: familial prevalence and HLA distribution.特发性扩张型心肌病：家族患病率与HLA分布
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10
Do specific HLA antigens predispose to ischaemic heart disease or idiopathic dilated cardiomyopathy?特定的人类白细胞抗原（HLA）抗原是否易患缺血性心脏病或特发性扩张型心肌病？
Br Heart J. 1994 Jan;71(1):76-8. doi: 10.1136/hrt.71.1.76.

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MICRODROPLET ASSAY OF HUMAN SERUM CYTOTOXINS.人血清细胞毒素的微滴分析法
Nature. 1964 Dec 5;204:998-1000. doi: 10.1038/204998b0.
2
HLA A, B and DR typing in idiopathic dilated cardiomyopathy: a search for immune response factors.特发性扩张型心肌病中的HLA A、B及DR分型：寻找免疫反应因子
Am J Cardiol. 1984 May 1;53(9):1326-30. doi: 10.1016/0002-9149(84)90088-2.
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Evaluation of suppressor immune regulatory function in idiopathic congestive cardiomyopathy and rheumatic heart disease.特发性充血性心肌病和风湿性心脏病中抑制性免疫调节功能的评估
Br Heart J. 1981 Oct;46(4):410-4. doi: 10.1136/hrt.46.4.410.
4
Diagnostic relevance of humoral and cytotoxic immune reactions in primary and secondary dilated cardiomyopathy.体液免疫和细胞毒性免疫反应在原发性和继发性扩张型心肌病中的诊断意义
Am J Cardiol. 1983 Nov 1;52(8):1072-8. doi: 10.1016/0002-9149(83)90535-0.
5
HLA and disease 1982--a survey.HLA与疾病（1982年）——一项调查
Immunol Rev. 1983;70:193-218. doi: 10.1111/j.1600-065x.1983.tb00715.x.
6
Genetic aspects of the cardiomyopathies.心肌病的遗传学方面。
Prog Med Genet. 1983;5:163-89.
7
Controlled trial of faecal occult blood testing in the detection of colorectal cancer.粪便潜血检测用于结直肠癌检测的对照试验。
Lancet. 1983 Jul 2;2(8340):1-4. doi: 10.1016/s0140-6736(83)90001-6.
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Dominant and recessive modes of inheritance in idiopathic cardiomyopathy.
Lancet. 1971 Nov 13;2(7733):1065-7. doi: 10.1016/s0140-6736(71)90383-7.
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Immunoglobulin binding in cardiomyopathic hearts.免疫球蛋白在心肌病心脏中的结合
Circulation. 1971 Oct;44(4):612-6. doi: 10.1161/01.cir.44.4.612.
10
Cardiac myosin induces myocarditis in genetically predisposed mice.心肌肌凝蛋白在具有遗传易感性的小鼠中诱发心肌炎。
J Immunol. 1987 Dec 1;139(11):3630-6.

特发性扩张型心肌病中的人类白细胞抗原

HLA antigens in idiopathic dilated cardiomyopathy.

作者信息

Limas C J, Limas C

机构信息

Department of Medicine, (Cardiovascular Section), University of Minnesota School of Medicine, Minneapolis 55455.

出版信息

Br Heart J. 1989 Nov;62(5):379-83. doi: 10.1136/hrt.62.5.379.

DOI:10.1136/hrt.62.5.379
PMID:2590590
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC1224837/
Abstract

Disturbances of humoral and cellular immunity are common in patients with idiopathic dilated cardiomyopathy and they may contribute to the initiation and maintenance of myocardial damage. HLA antigens were studied in 102 patients with dilated cardiomyopathy and a control hospital population. HLA-DR4 was significantly more common in patients with idiopathic cardiomyopathy (41 patients, 40%) than in the control group (123 patients, 24%). The distribution of other antigens was not significantly different in the two groups. The distribution of blood group antigens, immunoglobulin concentrations, and disease severity was similar in patients with the HLA-DR4 antigen and those without it. These results suggest that HLA-DR4 antigen may be a genetic marker for susceptibility to dilated cardiomyopathy.

摘要

特发性扩张型心肌病患者常出现体液免疫和细胞免疫紊乱，这些紊乱可能促使心肌损伤的发生和持续发展。对102例扩张型心肌病患者和医院对照组人群进行了HLA抗原研究。特发性心肌病患者（41例，40%）中HLA - DR4明显比对照组（123例，24%）更为常见。两组中其他抗原的分布无显著差异。HLA - DR4抗原阳性和阴性患者的血型抗原分布、免疫球蛋白浓度及疾病严重程度相似。这些结果表明，HLA - DR4抗原可能是扩张型心肌病易感性的遗传标志物。