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特发性扩张型心肌病中的人类白细胞抗原

HLA antigens in idiopathic dilated cardiomyopathy.

作者信息

Limas C J, Limas C

机构信息

Department of Medicine, (Cardiovascular Section), University of Minnesota School of Medicine, Minneapolis 55455.

出版信息

Br Heart J. 1989 Nov;62(5):379-83. doi: 10.1136/hrt.62.5.379.

DOI:10.1136/hrt.62.5.379
PMID:2590590
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC1224837/
Abstract

Disturbances of humoral and cellular immunity are common in patients with idiopathic dilated cardiomyopathy and they may contribute to the initiation and maintenance of myocardial damage. HLA antigens were studied in 102 patients with dilated cardiomyopathy and a control hospital population. HLA-DR4 was significantly more common in patients with idiopathic cardiomyopathy (41 patients, 40%) than in the control group (123 patients, 24%). The distribution of other antigens was not significantly different in the two groups. The distribution of blood group antigens, immunoglobulin concentrations, and disease severity was similar in patients with the HLA-DR4 antigen and those without it. These results suggest that HLA-DR4 antigen may be a genetic marker for susceptibility to dilated cardiomyopathy.

摘要

特发性扩张型心肌病患者常出现体液免疫和细胞免疫紊乱，这些紊乱可能促使心肌损伤的发生和持续发展。对102例扩张型心肌病患者和医院对照组人群进行了HLA抗原研究。特发性心肌病患者（41例，40%）中HLA - DR4明显比对照组（123例，24%）更为常见。两组中其他抗原的分布无显著差异。HLA - DR4抗原阳性和阴性患者的血型抗原分布、免疫球蛋白浓度及疾病严重程度相似。这些结果表明，HLA - DR4抗原可能是扩张型心肌病易感性的遗传标志物。

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