AMPK activates autophagy by phosphorylating ULK1.
作者信息
Mao Kai, Klionsky Daniel J
机构信息
Life Sciences Institute, University of Michigan, Ann Arbor, MI 48109-2216, USA.
出版信息
Circ Res. 2011 Apr 1;108(7):787-8. doi: 10.1161/RES.0b013e3182194c29.
Abstract
摘要
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本文引用的文献
1
AMPK and mTOR regulate autophagy through direct phosphorylation of Ulk1.AMPK 和 mTOR 通过直接磷酸化 Ulk1 来调节自噬。
Nat Cell Biol. 2011 Feb;13(2):132-41. doi: 10.1038/ncb2152. Epub 2011 Jan 23.
2
Phosphorylation of ULK1 (hATG1) by AMP-activated protein kinase connects energy sensing to mitophagy.ULK1（hATG1）的磷酸化由 AMP 激活的蛋白激酶介导，将能量感应与线粒体自噬连接起来。
Science. 2011 Jan 28;331(6016):456-61. doi: 10.1126/science.1196371. Epub 2010 Dec 23.
3
Is autophagy in response to ischemia and reperfusion protective or detrimental for the heart?自噬对缺血再灌注的反应对心脏是保护性的还是有害的？
Pediatr Cardiol. 2011 Mar;32(3):275-81. doi: 10.1007/s00246-010-9855-x. Epub 2010 Dec 19.
4
The association of AMPK with ULK1 regulates autophagy.AMPK 与 ULK1 的关联调节自噬。
PLoS One. 2010 Nov 3;5(11):e15394. doi: 10.1371/journal.pone.0015394.
5
The role of the Atg1/ULK1 complex in autophagy regulation.Atg1/ULK1 复合物在自噬调控中的作用。
Curr Opin Cell Biol. 2010 Apr;22(2):132-9. doi: 10.1016/j.ceb.2009.12.004. Epub 2010 Jan 6.
6
Atg101, a novel mammalian autophagy protein interacting with Atg13.Atg101，一种新型哺乳动物自噬蛋白，与 Atg13 相互作用。
Autophagy. 2009 Oct;5(7):973-9. doi: 10.4161/auto.5.7.9296. Epub 2009 Oct 18.
7
A novel, human Atg13 binding protein, Atg101, interacts with ULK1 and is essential for macroautophagy.一种新型的人类自噬相关蛋白13（Atg13）结合蛋白Atg101，与ULK1相互作用，对巨自噬至关重要。
Autophagy. 2009 Jul;5(5):649-62. doi: 10.4161/auto.5.5.8249. Epub 2009 Jul 20.
8
TAK1 activates AMPK-dependent cytoprotective autophagy in TRAIL-treated epithelial cells.TAK1在TRAIL处理的上皮细胞中激活AMPK依赖性的细胞保护性自噬。
EMBO J. 2009 Mar 18;28(6):677-85. doi: 10.1038/emboj.2009.8. Epub 2009 Feb 5.
9
AMPK phosphorylation of raptor mediates a metabolic checkpoint.Raptor的AMPK磷酸化介导代谢检查点。
Mol Cell. 2008 Apr 25;30(2):214-26. doi: 10.1016/j.molcel.2008.03.003.
10
Distinct roles of autophagy in the heart during ischemia and reperfusion: roles of AMP-activated protein kinase and Beclin 1 in mediating autophagy.自噬在心脏缺血再灌注过程中的不同作用：AMP激活的蛋白激酶和Beclin 1在介导自噬中的作用
Circ Res. 2007 Mar 30;100(6):914-22. doi: 10.1161/01.RES.0000261924.76669.36. Epub 2007 Mar 1.
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