免疫学：变装者诱导 T 细胞。
Immunology: Cross-dressers turn on T cells.
出版信息
Nature. 2011 Mar 31;471(7340):581-2. doi: 10.1038/471581a.
Abstract
Memory T cells remember viruses from previous infections, providing immunity by facilitating the killing of infected cells. For this, they exploit cross-dressing, the transfer of antigens between antigen-presenting cells.
摘要
记忆 T 细胞记得以前感染过的病毒，通过促进感染细胞的杀伤来提供免疫。为此，它们利用了变装术，即抗原在抗原呈递细胞之间的转移。
相似文献
1
Immunology: Cross-dressers turn on T cells.免疫学：变装者诱导 T 细胞。
Nature. 2011 Mar 31;471(7340):581-2. doi: 10.1038/471581a.
2
Cross-dressed dendritic cells drive memory CD8+ T-cell activation after viral infection.病毒感染后，异装树突状细胞驱动记忆性 CD8+T 细胞的激活。
Nature. 2011 Mar 31;471(7340):629-32. doi: 10.1038/nature09863.
3
Molecular and cellular requirements for enhanced antigen cross-presentation to CD8 cytotoxic T lymphocytes.增强抗原交叉呈递给CD8细胞毒性T淋巴细胞的分子和细胞要求。
J Immunol. 2007 Aug 15;179(4):2310-7. doi: 10.4049/jimmunol.179.4.2310.
4
Lung CD103+ dendritic cells efficiently transport influenza virus to the lymph node and load viral antigen onto MHC class I for presentation to CD8 T cells.肺 CD103+树突状细胞有效地将流感病毒运输到淋巴结，并将病毒抗原加载到 MHC Ⅰ类分子上，以供 CD8 T 细胞呈递。
J Immunol. 2011 Dec 1;187(11):6011-21. doi: 10.4049/jimmunol.1100987. Epub 2011 Oct 31.
5
Epitope-specific regulation of memory programming by differential duration of antigen presentation to influenza-specific CD8(+) T cells.通过向流感特异性CD8(+) T细胞呈递抗原的不同持续时间，对记忆编程进行表位特异性调节。
Immunity. 2014 Jul 17;41(1):127-40. doi: 10.1016/j.immuni.2014.06.007.
6
Direct CD4 help provision following interaction of memory CD4 and CD8 T cells with distinct antigen-presenting dendritic cells.直接提供 CD4 帮助，以在记忆性 CD4 和 CD8 T 细胞与不同的抗原呈递树突状细胞相互作用后。
J Immunol. 2010 Jul 15;185(2):1028-36. doi: 10.4049/jimmunol.0904209. Epub 2010 Jun 18.
7
Prolonged antigen presentation by immune complex-binding dendritic cells programs the proliferative capacity of memory CD8 T cells.免疫复合物结合树突状细胞的长期抗原呈递可调节记忆性 CD8 T 细胞的增殖能力。
J Exp Med. 2014 Jul 28;211(8):1637-55. doi: 10.1084/jem.20131692. Epub 2014 Jul 7.
8
Youth has its privileges: maturation inhibits DC cross-priming.年轻有其优势：成熟会抑制树突状细胞的交叉呈递。
Nat Immunol. 2006 Feb;7(2):125-6. doi: 10.1038/ni0206-125.
9
Duration of antigen availability influences the expansion and memory differentiation of T cells.抗原的持续存在影响 T 细胞的扩增和记忆分化。
J Immunol. 2011 Sep 1;187(5):2310-21. doi: 10.4049/jimmunol.1100363. Epub 2011 Jul 20.
10
Targeting antigen in mature dendritic cells for simultaneous stimulation of CD4+ and CD8+ T cells.靶向成熟树突状细胞中的抗原以同时刺激CD4+和CD8+ T细胞。
J Immunol. 2001 Apr 15;166(8):5250-7. doi: 10.4049/jimmunol.166.8.5250.
引用本文的文献
1
Distinct T helper cell-mediated antitumor immunity: T helper 2 cells in focus.独特的辅助性T细胞介导的抗肿瘤免疫：聚焦辅助性T2细胞
Cancer Pathog Ther. 2022 Nov 4;1(1):76-86. doi: 10.1016/j.cpt.2022.11.001. eCollection 2023 Jan.
2
Role of B cells as antigen presenting cells.B 细胞作为抗原呈递细胞的作用。
Front Immunol. 2022 Sep 8;13:954936. doi: 10.3389/fimmu.2022.954936. eCollection 2022.
3
Emerging Role of Extracellular Vesicles in Immune Regulation and Cancer Progression.细胞外囊泡在免疫调节和癌症进展中的新兴作用
Cancers (Basel). 2020 Nov 28;12(12):3563. doi: 10.3390/cancers12123563.
4
Factors Which Contribute to the Immunogenicity of Non-replicating Adenoviral Vectored Vaccines.导致非复制型腺病毒载体疫苗免疫原性的因素。
Front Immunol. 2020 May 19;11:909. doi: 10.3389/fimmu.2020.00909. eCollection 2020.
5
Antigen-loaded monocyte administration induces potent therapeutic antitumor T cell responses.给予负载抗原的单核细胞可诱导强大的治疗性抗肿瘤T细胞反应。
J Clin Invest. 2020 Feb 3;130(2):774-788. doi: 10.1172/JCI128267.
6
The Pathways for Layered Double Hydroxide Nanoparticles to Enhance Antigen (Cross)-Presentation on Immune Cells as Adjuvants for Protein Vaccines.层状双氢氧化物纳米颗粒作为蛋白质疫苗佐剂增强免疫细胞对抗原（交叉）呈递的途径。
Front Pharmacol. 2018 Sep 20;9:1060. doi: 10.3389/fphar.2018.01060. eCollection 2018.
7
Biological roles and potential applications of immune cell-derived extracellular vesicles.免疫细胞衍生的细胞外囊泡的生物学作用及潜在应用
J Extracell Vesicles. 2017 Nov 22;6(1):1400370. doi: 10.1080/20013078.2017.1400370. eCollection 2017.
8
Critical role for Sec22b-dependent antigen cross-presentation in antitumor immunity.Sec22b 依赖性抗原交叉呈递在抗肿瘤免疫中的关键作用。
J Exp Med. 2017 Aug 7;214(8):2231-2241. doi: 10.1084/jem.20170229. Epub 2017 Jun 29.
9
Molecular and Cellular Mechanisms of Antitumor Immune Response Activation by Dendritic Cells.树突状细胞激活抗肿瘤免疫反应的分子和细胞机制
Acta Naturae. 2016 Jul-Sep;8(3):17-30.
10
Influenza and Memory T Cells: How to Awake the Force.流感与记忆T细胞：如何唤醒这股力量。
Vaccines (Basel). 2016 Oct 13;4(4):33. doi: 10.3390/vaccines4040033.
本文引用的文献
1
Cross-dressed dendritic cells drive memory CD8+ T-cell activation after viral infection.病毒感染后，异装树突状细胞驱动记忆性 CD8+T 细胞的激活。
Nature. 2011 Mar 31;471(7340):629-32. doi: 10.1038/nature09863.
2
Bystander killing of cancer requires the cooperation of CD4(+) and CD8(+) T cells during the effector phase.旁观者效应杀伤肿瘤需要效应期 CD4(+)和 CD8(+)T 细胞的协同作用。
J Exp Med. 2010 Oct 25;207(11):2469-77. doi: 10.1084/jem.20092450. Epub 2010 Oct 4.
3
Designing CD8+ T cell vaccines: it's not rocket science (yet).设计 CD8+ T 细胞疫苗：并非高不可攀（但仍具挑战性）。
Curr Opin Immunol. 2010 Jun;22(3):402-10. doi: 10.1016/j.coi.2010.04.002. Epub 2010 May 4.
4
MHC class I/peptide transfer between dendritic cells overcomes poor cross-presentation by monocyte-derived APCs that engulf dying cells.树突状细胞之间的MHC I类/肽转移克服了吞噬死亡细胞的单核细胞来源的抗原呈递细胞交叉呈递能力差的问题。
J Immunol. 2009 Mar 15;182(6):3650-9. doi: 10.4049/jimmunol.0801532.
5
Dendritic cells cross-dressed with peptide MHC class I complexes prime CD8+ T cells.用肽-MHC I类复合物进行交叉呈递的树突状细胞可激活CD8+ T细胞。
J Immunol. 2006 Nov 1;177(9):6018-24. doi: 10.4049/jimmunol.177.9.6018.
6
Understanding presentation of viral antigens to CD8+ T cells in vivo: the key to rational vaccine design.了解病毒抗原在体内向CD8+ T细胞的呈递：合理疫苗设计的关键。
Annu Rev Immunol. 2005;23:651-82. doi: 10.1146/annurev.immunol.23.021704.115702.
7
A novel pathway of alloantigen presentation by dendritic cells.树突状细胞呈递同种异体抗原的新途径。
J Immunol. 2004 Oct 15;173(8):4828-37. doi: 10.4049/jimmunol.173.8.4828.
8
What is trogocytosis and what is its purpose?什么是噬细胞作用，其目的是什么？
Nat Immunol. 2003 Sep;4(9):815. doi: 10.1038/ni0903-815.
Zotero 插件