Department of Psychiatry, University of Pittsburgh School of Medicine, 3811 O’Hara St., Pittsburgh, PA 15213, USA.
Depress Anxiety. 2011 Apr;28(4):342-8. doi: 10.1002/da.20789. Epub 2011 Feb 24.
Although exposure and response prevention (ERP) is an effective treatment for youth with obsessive-compulsive disorder (OCD), the majority of studies, randomized clinical trials of individual therapy, find variability in treatment response. We evaluated the potential role of individual differences in OCD presentation, comorbid disorders, age, and gender on treatment effects. Moreover, we examined these potential effects in a group format in a naturalistic, clinic-based sample of patients.
Pediatric patients with a DSM-IV diagnosis of OCD (n=41) were treated with ERP in an intensive outpatient community-based program. OCD, mood, and anxiety symptom severity was measured at baseline, during treatment, and at discharge. Trajectories and predictors of treatment outcome were measured using linear growth models.
We found that group-based ERP was effective in reducing pediatric OCD symptom severity in a naturalistic treatment setting irrespective of age or gender. Furthermore, ERP was found to be effective at reducing depressive symptoms but not other anxiety symptoms. We also found inter-individual variability in the discharge levels of contamination, symmetry, and intrusive sexual thoughts and in the rate of severity reduction of intrusive sexual thoughts.
Group-based ERP is an effective treatment for children and adolescents with OCD. Several factors, including symptom dimensions and comorbid psychopathology, are associated with treatment response and outcome in this pediatric population.
尽管暴露和反应预防(ERP)是治疗青少年强迫症(OCD)的有效方法,但大多数研究,即个体治疗的随机临床试验,发现治疗反应存在差异。我们评估了 OCD 表现、共病障碍、年龄和性别等个体差异对治疗效果的潜在作用。此外,我们在一个自然主义的、基于诊所的患者群体中以小组形式检查了这些潜在的影响。
在一个以社区为基础的强化门诊计划中,患有 DSM-IV 强迫症诊断的儿科患者接受 ERP 治疗。在基线、治疗期间和出院时测量 OCD、情绪和焦虑症状的严重程度。使用线性增长模型测量治疗结果的轨迹和预测因素。
我们发现,无论年龄或性别如何,基于小组的 ERP 在自然治疗环境中都能有效降低儿科 OCD 症状的严重程度。此外,ERP 被发现可有效降低抑郁症状,但不能降低其他焦虑症状。我们还发现,在出院时的污染、对称和侵入性性思维的严重程度以及侵入性性思维严重程度的降低率方面存在个体间的差异。
基于小组的 ERP 是治疗儿童和青少年 OCD 的有效方法。在这个儿科人群中,包括症状维度和共病精神病理学在内的几个因素与治疗反应和结果有关。