Milewska-Bobula Bogumniła, Zebrowska Joanna, Olszaniecka Marzena, Pijanowska Stefania, Radziszewska-Konopka Marzanna, Lipka Bozena
Department of Infant Diseases, Children's Memorial Health Institute, Warsaw, Poland.
Med Wieku Rozwoj. 2010 Oct-Dec;14(4):370-3.
Assessment of intellectual development of 6-year-old children following asymptomatic or mildly symptomatic congenital cytomegalovirus infection in infancy.
A longitudinal, prospective cohort study concerning 38 (2%) children with congenital cytomegalovirus infection confirmed by specific serological and molecular tests, selected from the group of 1895 neonates preliminarily enrolled into the study. The first specialistic clinical assessment was performed during the neonatal and early infancy period, the second at the age of 12-18 months, and the final comprehensive clinical evaluation was carried out at the age of 6-6.5 years.
Psychological evaluation showed normal mental development (Intelligence Quotient ranged from 88 to 114), but 12 (32%) children showed abnormalities in speech development and in 3 (8%) poor visual-motor integration was observed. Emotional and social functioning indicate a normal level of maturity, but 14 (37%) children exhibited increased emotional sensitivity. Psychological assessment indicate that 6 (16%) children may have problems with school maturity.
Long-term follow-up of children with congenital cytomegalovirus infection is necessary, including those with a mild clinical course, in view of the possible late sequelae, especially concerning intellectual development and hearing impairment.
评估婴儿期无症状或症状轻微的先天性巨细胞病毒感染后6岁儿童的智力发育情况。
一项纵向、前瞻性队列研究，涉及38名（2%）经特异性血清学和分子检测确诊为先天性巨细胞病毒感染的儿童，这些儿童选自最初纳入研究的1895名新生儿。首次专科临床评估在新生儿期和婴儿早期进行，第二次在12至18个月龄时进行，最终的综合临床评估在6至6.5岁时进行。
心理评估显示智力发育正常（智商范围为88至114），但12名（32%）儿童存在言语发育异常，3名（8%）儿童存在视觉运动整合能力差的情况。情绪和社交功能表明成熟水平正常，但14名（37%）儿童表现出情绪敏感性增加。心理评估表明6名（16%）儿童可能存在学业成熟方面的问题。
鉴于可能出现的晚期后遗症，特别是在智力发育和听力损害方面，对先天性巨细胞病毒感染儿童进行长期随访是必要的，包括临床病程较轻的儿童。
