Changchun Institute of Optics, Fine Mechanics and Physics, Chinese Academy of Sciences, Laboratory of Excited State Processes, CAS, Changchun City, China.
J Biomed Opt. 2011 Mar;16(3):038001. doi: 10.1117/1.3552648.
Laser welding has the potential to become an effective method for wound closure and healing without sutures. Closure of skin incisions by laser welding with a combination of two near-infrared lasers (980 and 1064 nm), was performed for the first time in this study. One centimeter long, full-thickness incisions were made on the Wistar rat's dorsal skin. The efficiencies of laser-welding with different parameters were investigated. Incision-healing, histology examination, and a tensile strength test of incisions were recorded. Laser welding with the irradiance level of 15.9 W∕cm(2) for both 980 and 1064-nm lasers and exposure time of 5 s per spot in continuous wave mode yielded a more effective closure and healing with minimal thermal damage, faster recovery, and stronger apposition in comparison with a suturing technique. The conclusion is that skin welding with a combination of two near-infrared diode lasers can be a good candidate for incision closure, and further investigations are in progress for clinical use.
激光焊接有可能成为一种无需缝合即可有效闭合和愈合伤口的方法。本研究首次采用组合使用两种近红外激光（980nm 和 1064nm）对 Wistar 大鼠背部皮肤的 1 厘米长全层切口进行了激光焊接。研究了不同参数下激光焊接的效率。记录了切口的愈合情况、组织学检查和切口的拉伸强度测试。与缝合技术相比，使用辐照度为 15.9 W∕cm(2)的 980nm 和 1064nm 激光，每个光斑的曝光时间为 5s 的连续波模式进行激光焊接，可以实现更有效的闭合和愈合，且热损伤最小、恢复更快、贴合更牢固。结论是，组合使用两种近红外二极管激光进行皮肤焊接可能是一种很好的切口闭合方法，正在进行进一步的临床应用研究。
