Fernandez-Durango R, Triviño A, Ramirez J M, Garcia de Lacoba M, Ramirez A, Salazar J J, Fernandez-Cruz A, Gutkowska J
Diabetic, Hypertension and Obesity Unit, Hospital Universitario San Carlos, Ciudad Universitaria, Madrid, Spain.
Vision Res. 1990;30(9):1305-10. doi: 10.1016/0042-6989(90)90004-5.
Atrial natriuretic factor (ANF) concentration in the aqueous humor (AH) was studied in rabbits with experimental glaucoma induced by injecting alpha-chymotrypsin into the posterior chamber. In normal rabbit eyes, the ANF concentration in AH was 3.1 +/- 1.2 pg/ml (mean +/- SEM; n = 12), ranging from 0 to 5.8 pg/ml, whereas it was significantly higher in AH from glaucomatous rabbit eyes, being 81.0 +/- 9.8 pg/ml (n = 12). These findings were correlated with intraocular pressure (IOP), which was 13.0 +/- 2.4 mmHg (n = 12) in normal rabbit eyes and significantly greater in glaucomatous eyes: 24.4 +/- 3.0 mmHg (n = 12). Our data indicate that enhanced ANF release in AH during experimental glaucoma may play an important physiological role in modulating IOP.
通过向后房注射α-糜蛋白酶诱导实验性青光眼的兔子，对其房水（AH）中的心房利钠因子（ANF）浓度进行了研究。在正常兔眼中，AH中的ANF浓度为3.1±1.2 pg/ml（平均值±标准误；n = 12），范围为0至5.8 pg/ml，而在青光眼兔眼的AH中显著更高，为81.0±9.8 pg/ml（n = 12）。这些发现与眼内压（IOP）相关，正常兔眼的IOP为13.0±2.4 mmHg（n = 12），青光眼眼中显著更高：24.4±3.0 mmHg（n = 12）。我们的数据表明，实验性青光眼期间AH中ANF释放增强可能在调节IOP中发挥重要的生理作用。
