单纯疱疹病毒1型和2型之间的重组体：基因组结构分析及立即早期多肽的表达
Recombinants between herpes simplex virus types 1 and 2: analyses of genome structures and expression of immediate early polypeptides.
作者信息
Preston V G, Davison A J, Marsden H S, Timbury M C, Subak-Sharpe J H, Wilkie N M
出版信息
J Virol. 1978 Nov;28(2):499-517. doi: 10.1128/JVI.28.2.499-517.1978.
Abstract
Recombinants between temperature-sensitive mutants of herpes simplex virus types 1 (HSV-1) and 2 (HSV-2) were constructed. Using restriction endonucleases, we analyzed the genome composition of 17 intertypic recombinants and detected crossovers in every region of the genome. The virion DNA of one recombinant appeared to be largely "frozen" in two of the four possible genome arrangements of HSV. Knowledge of the genome structures of recombinants enabled us to physically map immediate early polypeptides. We present evidence that the immediate early polypeptide Vmw IE 110 of HSV-1 and its functionally equivalent polypeptide, Vmw IE 118, of HSV-2 may map in the repetitive sequences bounding the long unique region of HSV.
摘要
构建了1型单纯疱疹病毒（HSV - 1）和2型单纯疱疹病毒（HSV - 2）温度敏感突变体之间的重组体。我们使用限制性内切酶分析了17个型间重组体的基因组组成，并在基因组的每个区域检测到了交叉。一个重组体的病毒粒子DNA似乎在HSV四种可能的基因组排列中的两种中基本“固定”。重组体基因组结构的知识使我们能够对立即早期多肽进行物理定位。我们提供的证据表明，HSV - 1的立即早期多肽Vmw IE 110及其在功能上等效的HSV - 2多肽Vmw IE 118可能定位在界定HSV长单一区域的重复序列中。
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