在酵母酿酒酵母中，Ras2p 的膜定位和 Cdc25p 与 Ras2-GTP 的结合受蛋白激酶 A（PKA）的调节。
The membrane localization of Ras2p and the association between Cdc25p and Ras2-GTP are regulated by protein kinase A (PKA) in the yeast Saccharomyces cerevisiae.
机构信息
Department of Biochemical Engineering, School of Chemical Engineering and Technology, Tianjin University, Weijin Road 92, Nankai District, Tianjin 300072, PR China.
出版信息
FEBS Lett. 2011 Apr 20;585(8):1127-34. doi: 10.1016/j.febslet.2011.03.057. Epub 2011 Mar 30.
The Saccharomyces cerevisiae Ras2p has been suggested to be a target in the feedback regulation of Ras-cAMP pathway. This work proves that the Ras2p localization is regulated by PKA activity, and that PKA down-regulates Ras2p activity and the protein association between Cdc25p and Ras2-GTP, which is due to a reduced Ras2-GEF Cdc25p activity. These results suggest that Ras2p localization and Ras2-GEF activity of Cdc25p play roles in the feedback regulation of Ras2p in the Ras-cAMP pathway.
酿酒酵母 Ras2p 被认为是 Ras-cAMP 途径反馈调节的靶标。本工作证明 Ras2p 的定位受 PKA 活性的调节，PKA 下调 Ras2p 的活性和 Cdc25p 与 Ras2-GTP 之间的蛋白结合，这是由于 Ras2-GEF Cdc25p 活性降低所致。这些结果表明，Ras2p 的定位和 Cdc25p 的 Ras2-GEF 活性在 Ras-cAMP 途径中 Ras2p 的反馈调节中起作用。
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