Chinese Center for Disease Control and Prevention Institute for Viral Disease Control and Prevention, Beijing 100052, PR China.
Vaccine. 2011 May 17;29(22):3905-8. doi: 10.1016/j.vaccine.2011.03.030. Epub 2011 Mar 30.
To evaluate the effectiveness of a Chinese hamster ovary cell derived hepatitis B vaccine in a country community in Hebei Province, PR China.
A cross-sectional investigation was carried out in 4 of 7 randomly selected country communities in Zhengding County in 2005. All of the children who were born between 1997 and 1999 were selected as study objects. Their serum samples were taken to test for HBV markers, and HBsAg prevalence was compared to that of the same age group before hepatitis B vaccination in 1983. In addition, for HBsAg positive children, their mothers were visited and tested for serum HBV markers, in order to distinguish maternal HBV transmissions.
Among the 2205 children of the selected birth cohort, 1696 (76.9%) were visited. The prevalence of HBsAg was 0.53%, and by comparing to that of before hepatitis B vaccination, the effectiveness was 95.3%, similar to that of yeast derived hepatitis B vaccines. Among 7 mothers of HBsAg positive children, 5 were HBsAg positive, indicating maternal HBV transmissions; and although one mother was HBsAg negative, her kid was not vaccinated, which indicates a horizontal transmission. As for the other kid, he was adopted and the HBV infection status of his birth mother was unknown.
The effectiveness of the CHO derived hepatitis B vaccine is comparable to yeast derived ones, and after the hepatitis B vaccination maternal transmission is the most important route of spreading HBV.
评估中国仓鼠卵巢细胞乙型肝炎疫苗在中国河北省一个农村社区的效果。
2005 年在正定县随机选择的 7 个农村社区中的 4 个进行横断面调查。选择 1997 年至 1999 年期间出生的所有儿童作为研究对象。采集他们的血清样本检测 HBV 标志物，并与 1983 年乙型肝炎疫苗接种前同年龄组的 HBsAg 流行率进行比较。此外，对于 HBsAg 阳性儿童，对其母亲进行访视并检测血清 HBV 标志物，以区分母婴 HBV 传播。
在所选择的出生队列的 2205 名儿童中，有 1696 名（76.9%）接受了访视。HBsAg 的流行率为 0.53%，与乙型肝炎疫苗接种前相比，有效性为 95.3%，与酵母源性乙型肝炎疫苗相似。在 7 名 HBsAg 阳性儿童的母亲中，有 5 名 HBsAg 阳性，表明母婴 HBV 传播；虽然有 1 名母亲 HBsAg 阴性，但她的孩子没有接种疫苗，表明存在水平传播。对于另一个孩子，他是被收养的，他生母的 HBV 感染状况未知。
CHO 来源的乙型肝炎疫苗的效果与酵母源性疫苗相当，接种乙型肝炎疫苗后母婴传播是 HBV 传播的最重要途径。
