Institute for Viral Disease Control and Prevention, Chinese Center for Disease Control and Prevention, Changing District, Beijing 100052, PR China.
Vaccine. 2012 Mar 9;30(12):2051-3. doi: 10.1016/j.vaccine.2012.01.052. Epub 2012 Jan 30.
To evaluate the long-term efficacy of Chinese hamster ovary (CHO) cell derived hepatitis B vaccine in country community in China.
A cross-sectional investigation was carried out. Children who were born between 1997 and 1999 and vaccinated with the three doses of CHO-derived hepatitis B vaccine were selected as study objects. Their serum samples were taken to test for hepatitis B virus (HBV) markers, and the results were compared to that before vaccination. In addition, for HBsAg positive children, their mothers were visited.
1254 Children were enrolled in the study. The prevalence of HBsAg was 0.24% and the vaccine efficacy was 97.0%, similar to that of yeast derived hepatitis vaccines. Among 3 mothers of HBsAg positive children, 2 were HBsAg positive, indicating maternal HBV transmissions.
The long-term efficacy of the CHO-derived hepatitis B vaccine is good and after vaccination maternal transmission is the most important route of spreading HBV.
评估中国农村社区乙型肝炎病毒（HBV）基因工程疫苗（汉逊酵母）的长期免疫效果。
采用现况调查方法，选择 1997 年至 1999 年间出生、全程接种过 3 剂汉逊酵母乙肝疫苗的儿童为研究对象，采集血清标本检测 HBV 标志物，与接种前比较，并对 HBsAg 阳性儿童的母亲进行访视。
共纳入 1254 名儿童，HBsAg 阳性率为 0.24%，疫苗保护率为 97.0%，与酵母乙肝疫苗类似。3 名 HBsAg 阳性儿童的母亲中，有 2 名 HBsAg 阳性，提示存在母婴传播。
汉逊酵母乙肝疫苗长期免疫效果良好，接种后母婴传播是 HBV 最重要的传播途径。
