原发性血脂异常患者血清磷脂油酸与胰岛素抵抗呈负相关。

Inverse association between serum phospholipid oleic acid and insulin resistance in subjects with primary dyslipidaemia.

机构信息

Endocrinology and Nutrition Department, Institut d'Investigacions Biomèdiques August Pi Sunyer (IDIBAPS), Hospital Clínic, Barcelona, Spain.

出版信息

Clin Nutr. 2011 Oct;30(5):590-2. doi: 10.1016/j.clnu.2011.02.008. Epub 2011 Mar 31.

DOI:10.1016/j.clnu.2011.02.008

PMID:21458117

Abstract

BACKGROUND & AIMS: Data on intake of oleic acid (OA) and insulin resistance (IR) are inconsistent. We investigated whether OA in serum phosphatidylcholine relates to surrogate measures of IR in dyslipidaemic subjects from a Mediterranean population.

METHODS

Cross-sectional study of 361 non-diabetic subjects (205 men, 156 women; mean age 44 and 46 y, respectively; BMI 25.7 kg/m(2)). IR was diagnosed by BMI and HOMA values using published criteria validated against the euglycemic clamp. Alternatively, IR was defined by the 75th percentile of HOMA-IR of our study population. The fatty acid composition of serum phosphatidylcholine was determined by gas-chromatography.

RESULTS

The mean (±SD) proportion of OA was 11.7 ± 2.0%. Ninety-two subjects (25.5%) had IR. By adjusted logistic regression, including the proportions of other fatty acids known to relate to IR, the odds ratios (OR) (95% confidence intervals) for IR were 0.75 (0.62-0.92) for 1% increase in OA and 0.84 (0.71-0.99) for 1% increase in linoleic acid. Other fatty acids were unrelated to IR. When using the alternate definition of IR, OA remained a significant predictor (0.80 [0.65-0.99]).

CONCLUSIONS

Higher phospholipid proportions of OA relate to less IR, suggesting an added benefit of increasing olive oil intake within the Mediterranean diet.

摘要

背景与目的

关于油酸（OA）摄入和胰岛素抵抗（IR）的数据不一致。我们研究了地中海人群血脂异常患者血清磷酯酰胆碱中的 OA 是否与 IR 的替代测量值有关。

方法

对 361 例非糖尿病患者（男性 205 例，女性 156 例；平均年龄分别为 44 岁和 46 岁；BMI 为 25.7kg/m²）进行横断面研究。IR 根据 BMI 和 HOMA 值用已发表的标准诊断，这些标准是针对我们研究人群的高血糖钳夹法进行验证的。或者，IR 也可以通过我们研究人群的 HOMA-IR 第 75 百分位数来定义。血清磷酯酰胆碱的脂肪酸组成通过气相色谱法确定。

结果

OA 的平均（±SD）比例为 11.7±2.0%。92 例（25.5%）患者存在 IR。通过包括已知与 IR 相关的其他脂肪酸比例的调整 logistic 回归，OA 增加 1%的 OR（95%置信区间）为 0.75（0.62-0.92），亚油酸增加 1%的 OR 为 0.84（0.71-0.99）。其他脂肪酸与 IR 无关。当使用 IR 的替代定义时，OA 仍然是一个显著的预测因子（0.80 [0.65-0.99]）。